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2007 5
2008 7
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2010 7
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A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
Ellis MJ, et al. Nat Commun 2019. Among authors: Porwollik S. PMID 30643129 Free PMC article.
Here, we sought to identify inhibitors of intracellular S. Tm replication by conducting parallel chemical screens against S. ...We report on the antimicrobial activity of the psychoactive drug metergoline, which is specific against intracellular S. Tm. ...
Here, we sought to identify inhibitors of intracellular S. Tm replication by conducting parallel chemical screens against S. . …
Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria
Reinink P, et al. J Exp Med 2019. Among authors: Porwollik S. PMID 30804000 Free PMC article.
Salmonella species are among the world's most prevalent pathogens. Because the cell wall interfaces with the host, we designed a lipidomics approach to reveal pathogen-specific cell wall compounds. Among the molecules differentially expressed between Salmonella Paratyphi and S. Typhi, we focused on lipids that are enriched in S. ...
Salmonella species are among the world's most prevalent pathogens. Because the cell wall interfaces with the host, we designed a lipi …
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
McClelland M, et al. Nature 2001. Among authors: Porwollik S. PMID 11677609
Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. ...
Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of cl …
Contribution of Asparagine Catabolism to Salmonella Virulence
McLaughlin PA, et al. Infect Immun 2017. Among authors: Porwollik S. PMID 27849183 Free PMC article.
We previously showed that l-asparaginase II produced by Salmonella enterica serovar Typhimurium (S Typhimurium) inhibits T cell responses and mediates virulence. ...Importantly, we determined that, in a murine model of infection, S Typhimurium lacking both l-asparaginase I and II genes competes poorly with wild-type S Typhimurium for colonization of target tissues. ...
We previously showed that l-asparaginase II produced by Salmonella enterica serovar Typhimurium (S Typhimurium) inhibits T cell respo …
Genome-Wide Comparative Functional Analyses Reveal Adaptations of Salmonella sv. Newport to a Plant Colonization Lifestyle
de Moraes MH, et al. Front Microbiol 2018. Among authors: Porwollik S. PMID 29867794 Free PMC article.
Newport and contributed to the strain's fitness in tomatoes. The papA gene was present in about 25% of sv. Newport Group III genomes and generally absent from other Salmonella genomes. ...
Newport and contributed to the strain's fitness in tomatoes. The papA gene was present in about 25% of sv. Newport Group III genomes …
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