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Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.
Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Reardon S, Posgai AL, Bacher R, Luning Prak ET, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. Medina-Serpas MA, et al. Among authors: posgai al. Cell Rep. 2026 Mar 23;45(4):117144. doi: 10.1016/j.celrep.2026.117144. Online ahead of print. Cell Rep. 2026. PMID: 41875135 Free article.
Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.
Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM. Rawat P, et al. Among authors: posgai al. Sci Adv. 2026 Feb 13;12(7):eadx7448. doi: 10.1126/sciadv.adx7448. Epub 2026 Feb 13. Sci Adv. 2026. PMID: 41686902 Free PMC article.
TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes.
Mayer-Blackwell K, Minervina A, Pogorelyy M, Rawat P, Shapiro MR, Peters LD, Ford ES, Posgai AL, Vegesana K, Minot S, Koelle DM, Greiff V, Bradley P, Brusko TM, Thomas PG, Fiore-Gartland A. Mayer-Blackwell K, et al. Among authors: posgai al. PLoS Comput Biol. 2026 Jan 16;22(1):e1013767. doi: 10.1371/journal.pcbi.1013767. eCollection 2026 Jan. PLoS Comput Biol. 2026. PMID: 41544105 Free PMC article.
TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes.
Mayer-Blackwell K, Minervina A, Pogorelyy M, Rawat P, Shapiro MR, Peters LD, Ford ES, Posgai AL, Vengesana K, Minot S, Koelle DM, Greiff V, Bradley P, Brusko TM, Thomas PG, Fiore-Gartland A. Mayer-Blackwell K, et al. Among authors: posgai al. bioRxiv [Preprint]. 2025 Jul 23:2025.07.18.665436. doi: 10.1101/2025.07.18.665436. bioRxiv. 2025. Update in: PLoS Comput Biol. 2026 Jan 16;22(1):e1013767. doi: 10.1371/journal.pcbi.1013767. PMID: 40777454 Free PMC article. Updated. Preprint.
66 results