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Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs.
Bepler T, Morin A, Rapp M, Brasch J, Shapiro L, Noble AJ, Berger B. Bepler T, et al. Nat Methods. 2019 Nov;16(11):1153-1160. doi: 10.1038/s41592-019-0575-8. Epub 2019 Oct 7. Nat Methods. 2019. PMID: 31591578 Free PMC article.
Current computational approaches find many false positives and require ad hoc postprocessing, especially for unusually shaped particles. To address these shortcomings, we develop Topaz, an efficient and accurate particle-picking pipeline using neural …
Current computational approaches find many false positives and require ad hoc postprocessing, especially for unusually shaped particles …