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Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.
McIntosh CH, Demuth HU, Kim SJ, Pospisilik JA, Pederson RA. McIntosh CH, et al. Among authors: pospisilik ja. Int J Biochem Cell Biol. 2006;38(5-6):860-72. doi: 10.1016/j.biocel.2005.12.013. Epub 2006 Jan 11. Int J Biochem Cell Biol. 2006. PMID: 16442340 Review.
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs.
Hinke SA, Pospisilik JA, Demuth HU, Mannhart S, Kühn-Wache K, Hoffmann T, Nishimura E, Pederson RA, McIntosh CH. Hinke SA, et al. Among authors: pospisilik ja. J Biol Chem. 2000 Feb 11;275(6):3827-34. doi: 10.1074/jbc.275.6.3827. J Biol Chem. 2000. PMID: 10660533
Metabolism of glucagon by dipeptidyl peptidase IV (CD26).
Pospisilik JA, Hinke SA, Pederson RA, Hoffmann T, Rosche F, Schlenzig D, Glund K, Heiser U, McIntosh CH, Demuth H. Pospisilik JA, et al. Regul Pept. 2001 Jan 12;96(3):133-41. doi: 10.1016/s0167-0115(00)00170-1. Regul Pept. 2001. PMID: 11111019
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.
Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA. Pospisilik JA, et al. Diabetes. 2002 Apr;51(4):943-50. doi: 10.2337/diabetes.51.4.943. Diabetes. 2002. PMID: 11916911
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.
Pospisilik JA, Stafford SG, Demuth HU, McIntosh CH, Pederson RA. Pospisilik JA, et al. Diabetes. 2002 Sep;51(9):2677-83. doi: 10.2337/diabetes.51.9.2677. Diabetes. 2002. PMID: 12196458
A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.
Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA. Lynn FC, et al. Among authors: pospisilik ja. FASEB J. 2003 Jan;17(1):91-3. doi: 10.1096/fj.02-0243fje. Epub 2002 Nov 15. FASEB J. 2003. PMID: 12475913
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.
Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA. Pamir N, et al. Among authors: pospisilik ja. Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. doi: 10.1152/ajpendo.00270.2002. Epub 2003 Jan 21. Am J Physiol Endocrinol Metab. 2003. PMID: 12540373
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.
Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA. Pospisilik JA, et al. Diabetes. 2003 Mar;52(3):741-50. doi: 10.2337/diabetes.52.3.741. Diabetes. 2003. PMID: 12606516
Dipeptidyl peptidase IV inhibition in animal models of diabetes.
Pospisilik JA, Ehses JA, Doty T, McIntosh CH, Demuth HU, Pederson RA. Pospisilik JA, et al. Adv Exp Med Biol. 2003;524:281-91. doi: 10.1007/0-306-47920-6_34. Adv Exp Med Biol. 2003. PMID: 12675250 No abstract available.
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.
Ehses JA, Casilla VR, Doty T, Pospisilik JA, Winter KD, Demuth HU, Pederson RA, McIntosh CH. Ehses JA, et al. Among authors: pospisilik ja. Endocrinology. 2003 Oct;144(10):4433-45. doi: 10.1210/en.2002-0068. Epub 2003 Jun 19. Endocrinology. 2003. PMID: 12960055
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