Possemato R - Search Results

1

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.

Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R. Jackson-Grusby L, et al. Among authors: possemato r. Nat Genet. 2001 Jan;27(1):31-9. doi: 10.1038/83730. Nat Genet. 2001. PMID: 11137995

2

Flp recombinase regulated lacZ expression at the ROSA26 locus.

Possemato R, Eggan K, Moeller BJ, Jaenisch R, Jackson-Grusby L. Possemato R, et al. Genesis. 2002 Feb;32(2):184-6. doi: 10.1002/gene.10039. Genesis. 2002. PMID: 11857816 No abstract available.

3

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Possemato R, et al. Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. Nature. 2011. PMID: 21760589 Free PMC article.

4

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. Birsoy K, et al. Among authors: possemato r. Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2. Nat Genet. 2013. PMID: 23202129 Free PMC article.

5

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. Alvarez SW, et al. Among authors: possemato r. Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22. Nature. 2017. PMID: 29168506 Free PMC article.

6

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Birsoy K, et al. Among authors: possemato r. Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16. Nature. 2014. PMID: 24670634 Free PMC article.

7

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. Kim D, et al. Among authors: possemato rl. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. Nature. 2015. PMID: 25855294 Free PMC article.

8

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Birsoy K, Sabatini DM, Possemato R. Birsoy K, et al. Among authors: possemato r. Nat Med. 2012 Jul 6;18(7):1022-3. doi: 10.1038/nm.2870. Nat Med. 2012. PMID: 22772555 No abstract available.

9

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Pacold ME, et al. Among authors: possemato r. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110680 Free PMC article.

10

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Garcia-Bermudez J, et al. Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941933 Free PMC article.

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