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Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection.
Postigo A, Martin MC, Dodding MP, Way M. Postigo A, et al. Cell Microbiol. 2009 Aug;11(8):1208-18. doi: 10.1111/j.1462-5822.2009.01327.x. Epub 2009 Apr 22. Cell Microbiol. 2009. PMID: 19388902 Free PMC article.
F1L is a functional Bcl-2 homologue that inhibits apoptosis at the mitochondria during vaccinia infection. However, the extent and timing of cell death during DeltaF1L virus infection suggest that additional viral effectors cooperate with F1L to limit apoptosis. Here we re …
F1L is a functional Bcl-2 homologue that inhibits apoptosis at the mitochondria during vaccinia infection. However, the extent and ti …
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.
Gerlic M, Faustin B, Postigo A, Yu EC, Proell M, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, Matsuzawa S, Reed JC. Gerlic M, et al. Among authors: postigo a. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7808-13. doi: 10.1073/pnas.1215995110. Epub 2013 Apr 19. Proc Natl Acad Sci U S A. 2013. PMID: 23603272 Free PMC article.
Furthermore, we found that a hexapeptide from F1L is necessary and sufficient for inhibiting the NLRP1 inflammasome in vitro, thus identifying a peptidyl motif required for binding and inhibiting NLRP1. ...Altogether, these findings reveal a unique viral mech …
Furthermore, we found that a hexapeptide from F1L is necessary and sufficient for inhibiting the NLRP1 inflammasome in vitro, thus id …
Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication.
Postigo A, Ramsden AE, Howell M, Way M. Postigo A, et al. Cell Rep. 2017 May 2;19(5):1022-1032. doi: 10.1016/j.celrep.2017.04.025. Cell Rep. 2017. PMID: 28467896 Free PMC article.
We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected because ATR plays a fundamental nuclear role in maintaining host genome integrity. ...
We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected becau …
The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors.
Postigo A, Way M. Postigo A, et al. J Virol. 2012 Jan;86(1):203-13. doi: 10.1128/JVI.05817-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013032 Free PMC article.
However, N1, a potent virulence factor, is reported to be antiapoptotic and to interact with Bax. Here we investigated whether vaccinia virus inhibits Bak/Bax-dependent apoptosis via the cooperative action of F1 and N1. ...
However, N1, a potent virulence factor, is reported to be antiapoptotic and to interact with Bax. Here we investigated whether vaccin …
Viral inhibitors reveal overlapping themes in regulation of cell death and innate immunity.
Postigo A, Ferrer PE. Postigo A, et al. Microbes Infect. 2009 Nov;11(13):1071-8. doi: 10.1016/j.micinf.2009.08.012. Epub 2009 Sep 4. Microbes Infect. 2009. PMID: 19733680 Free PMC article. Review.
Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools to investigate the mechanisms behind the control of the mitochondrial checkpoint of apoptosis. Concurrently, a number of viral inhibit …
Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools t …
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.
Postigo A, Cross JR, Downward J, Way M. Postigo A, et al. Cell Death Differ. 2006 Oct;13(10):1651-62. doi: 10.1038/sj.cdd.4401853. Epub 2006 Jan 27. Cell Death Differ. 2006. PMID: 16439990
As a consequence, F1L prevents Bak activation, oligomerization and interaction with active Bax, all critical steps in the induction of apoptosis. ...
As a consequence, F1L prevents Bak activation, oligomerization and interaction with active Bax, all critical steps in the induction o …
Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur.
Cross JR, Postigo A, Blight K, Downward J. Cross JR, et al. Among authors: postigo a. Cell Death Differ. 2008 Jun;15(6):997-1008. doi: 10.1038/cdd.2008.14. Epub 2008 Feb 15. Cell Death Differ. 2008. PMID: 18274554
It is currently unclear whether mitochondria play a passive role in the initiation of apoptosis, remaining unaffected by cell stresses until Bax and Bak are active, or whether they actively participate in Bax/Bak activation. ...We suggest that the ability of mitochondria t …
It is currently unclear whether mitochondria play a passive role in the initiation of apoptosis, remaining unaffected by cell stresse …
The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma.
Sánchez-Tilló E, Fanlo L, Siles L, Montes-Moreno S, Moros A, Chiva-Blanch G, Estruch R, Martinez A, Colomer D, Győrffy B, Roué G, Postigo A. Sánchez-Tilló E, et al. Among authors: postigo a. Cell Death Differ. 2014 Feb;21(2):247-57. doi: 10.1038/cdd.2013.123. Epub 2013 Sep 6. Cell Death Differ. 2014. PMID: 24013721 Free PMC article.
Lastly, salinomycin and doxorubicin display a synergistic effect in established and primary MCL cells. These results identify ZEB1 in MCL where it promotes cell proliferation, enhanced tumor growth and a differential response to chemotherapy drugs. ZEB1 could thus p …
Lastly, salinomycin and doxorubicin display a synergistic effect in established and primary MCL cells. These results identify ZEB1 in …
ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.
Papadopoulou V, Postigo A, Sánchez-Tilló E, Porter AC, Wagner SD. Papadopoulou V, et al. Among authors: postigo a. Biochem J. 2010 Apr 14;427(3):541-50. doi: 10.1042/BJ20091578. Biochem J. 2010. PMID: 20175752
Transfection of ZEB1 cDNA caused a reduction in BCL6 expression and a mutated ZEB1, incapable of binding CtBP, lacked this effect. siRNA (small interfering RNA)-mediated knockdown of ZEB1 or CtBP produced an increase in BCL6 mRNA. We propose that HSS-4.4 is a
Transfection of ZEB1 cDNA caused a reduction in BCL6 expression and a mutated ZEB1, incapable of binding CtBP, lacked this eff …
Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition.
Zhang HS, Postigo AA, Dean DC. Zhang HS, et al. Among authors: postigo aa. Cell. 1999 Apr 2;97(1):53-61. doi: 10.1016/s0092-8674(00)80714-x. Cell. 1999. PMID: 10199402
It associates with a number of cellular proteins; however, the nature of these interactions and their relative significance in cell cycle regulation are still unclear. ...Thus, a major role of E2F in cell cycle regulation is assembly of this repressor complex. We de …
It associates with a number of cellular proteins; however, the nature of these interactions and their relative significance in cell c …
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