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Potential serum biomarkers from a metabolomics study of autism.
Wang H, Liang S, Wang M, Gao J, Sun C, Wang J, Xia W, Wu S, Sumner SJ, Zhang F, Sun C, Wu L. Wang H, et al. J Psychiatry Neurosci. 2016 Jan;41(1):27-37. doi: 10.1503/jpn.140009. J Psychiatry Neurosci. 2016. PMID: 26395811 Free PMC article.
We performed a metabolomics analysis of serum to identify potential biomarkers for the early diagnosis and clinical evaluation of autism. ...Other limitations include the need to perform test-retest assessment within the same individual and the …
We performed a metabolomics analysis of serum to identify potential biomarkers for the early diagnosis and clini …
Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring.
Ritz B, Yan Q, Uppal K, Liew Z, Cui X, Ling C, Inoue K, von Ehrenstein O, Walker DI, Jones DP. Ritz B, et al. Autism Res. 2020 Aug;13(8):1258-1269. doi: 10.1002/aur.2311. Epub 2020 Jun 4. Autism Res. 2020. PMID: 32496662
We conducted a population-based study relying on autism diagnoses retrieved from California Department of Developmental Services record. ...In the future, these insights may help identify biomarkers for early autism diagnosis and treatment or preventiv …
We conducted a population-based study relying on autism diagnoses retrieved from California Department of Developmental Servic …
Metabolomics analysis of maternal serum exposed to high air pollution during pregnancy and risk of autism spectrum disorder in offspring.
Kim JH, Yan Q, Uppal K, Cui X, Ling C, Walker DI, Heck JE, von Ehrenstein OS, Jones DP, Ritz B. Kim JH, et al. Environ Res. 2021 May;196:110823. doi: 10.1016/j.envres.2021.110823. Epub 2021 Feb 4. Environ Res. 2021. PMID: 33548296 Free PMC article.
BACKGROUND: Previously, numerous epidemiologic studies reported an association between autism spectrum disorder (ASD) and exposure to air pollution during pregnancy. However, there have been no metabolomics studies investigating the impact of pr …
BACKGROUND: Previously, numerous epidemiologic studies reported an association between autism spectrum disorder (ASD) a …
(1)H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome.
Gagliano A, Murgia F, Capodiferro AM, Tanca MG, Hendren A, Falqui SG, Aresti M, Comini M, Carucci S, Cocco E, Lorefice L, Roccella M, Vetri L, Sotgiu S, Zuddas A, Atzori L. Gagliano A, et al. J Clin Med. 2022 Nov 1;11(21):6493. doi: 10.3390/jcm11216493. J Clin Med. 2022. PMID: 36362721 Free PMC article.
We confirmed a unique serum metabolomic profile of PANS compared with both ASD and neurotypical subjects, distinguishing PANS as a pathophysiological entity per se. ...Metabolomics-based approaches could contribute to the identification of novel ASD and PANS …
We confirmed a unique serum metabolomic profile of PANS compared with both ASD and neurotypical subjects, distinguishing PANS …
Studying Autism Using Untargeted Metabolomics in Newborn Screening Samples.
Courraud J, Ernst M, Svane Laursen S, Hougaard DM, Cohen AS. Courraud J, et al. J Mol Neurosci. 2021 Jul;71(7):1378-1393. doi: 10.1007/s12031-020-01787-2. Epub 2021 Jan 30. J Mol Neurosci. 2021. PMID: 33515432 Free PMC article.
Main risk factors of autism spectrum disorder (ASD) include both genetic and non-genetic factors, especially prenatal and perinatal events. Newborn screening dried blood spot (DBS) samples have great potential for the study of early biochemical markers …
Main risk factors of autism spectrum disorder (ASD) include both genetic and non-genetic factors, especially prenatal and peri …
(1)H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study.
Correia BSB, de Moraes Pontes JG, Nani JVS, Villalta F, Mor NC, Bordini D, Brunoni D, Brentani H, Mari JJ, Hayashi MAF, Tasic L. Correia BSB, et al. ACS Chem Neurosci. 2023 Mar 15;14(6):1137-1145. doi: 10.1021/acschemneuro.2c00735. Epub 2023 Feb 21. ACS Chem Neurosci. 2023. PMID: 36808953
Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been successfully employed in several mental disorder studies. ...We demonstrate the value of applying metabolomics and lipidomics to identify potential biomarkers for cli …
Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been successfully employed in several mental disorder st …
Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data.
Dai S, Lin J, Hou Y, Luo X, Shen Y, Ou J. Dai S, et al. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871. eCollection 2023. Front Mol Neurosci. 2023. PMID: 36818658 Free PMC article.
INTRODUCTION: Previous studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism …
INTRODUCTION: Previous studies have suggested that the dysregulation of purine metabolism may be associated with autism spectr …
Unraveling the metabolomic architecture of autism in a large Danish population-based cohort.
Ottosson F, Russo F, Abrahamsson A, MacSween N, Courraud J, Skogstrand K, Melander O, Ericson U, Orho-Melander M, Cohen AS, Grove J, Mortensen PB, Hougaard DM, Ernst M. Ottosson F, et al. BMC Med. 2024 Jul 19;22(1):302. doi: 10.1186/s12916-024-03516-7. BMC Med. 2024. PMID: 39026322 Free PMC article.
Here, we use untargeted metabolomics to characterize the neonatal metabolome from dried blood spots collected shortly after birth. ...CONCLUSIONS: Cyclo-leucine-proline and 5-AVAB are associated with future diagnosis of autism in Danish neonates, both represe …
Here, we use untargeted metabolomics to characterize the neonatal metabolome from dried blood spots collected shortly after bi …