Seco-cyclic phorbol derivatives and their anti-HIV-1 activities.
Huang X, Huang X, Li Q, Ma M, Cui Y, Yang L, Wang H, Luo R, Chen J, Yang J, Lin J, Li D, Zheng Y, Zhang J.
Huang X, et al.
Chin J Nat Med. 2024 Apr;22(4):365-374. doi: 10.1016/S1875-5364(24)60630-8.
Chin J Nat Med. 2024.
PMID: 38658099
The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, and C9 of phorbol. Concurrently, the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-l …
The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, and C9 of …