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Refining estimates of prescription durations by using observed covariates in pharmacoepidemiological databases: an application of the reverse waiting time distribution.
Støvring H, Pottegård A, Hallas J. Støvring H, et al. Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):900-908. doi: 10.1002/pds.4216. Epub 2017 May 3. Pharmacoepidemiol Drug Saf. 2017. PMID: 28466973
METHODS: We developed an estimation algorithm based on maximum likelihood estimation for the reverse waiting time distribution (WTD), which is the distribution of time from the last prescription of each patient within a time window to the end of the time window. ...For 70- …
METHODS: We developed an estimation algorithm based on maximum likelihood estimation for the reverse waiting time distribution (WTD), which …
Physicians' and pharmacies' overview of patients' medication. An analysis of fidelity coefficients.
Pottegård A, Hallas J. Pottegård A, et al. Eur J Clin Pharmacol. 2011 Sep;67(9):919-24. doi: 10.1007/s00228-011-1026-3. Epub 2011 Mar 12. Eur J Clin Pharmacol. 2011. PMID: 21399945
We have assessed this overview by measuring the 'fidelity coefficient', a measure of the extent to which a drug user has a preference for one prescriber or one pharmacy. ...Among the factors associated with a high FC(presc) and high FC(pharm) were olde …
We have assessed this overview by measuring the 'fidelity coefficient', a measure of the extent to which a drug user has a
Pharmaceutical interventions on prescription problems in a Danish pharmacy setting.
Pottegård A, Hallas J, Søndergaard J. Pottegård A, et al. Int J Clin Pharm. 2011 Dec;33(6):1019-27. doi: 10.1007/s11096-011-9580-4. Epub 2011 Nov 15. Int J Clin Pharm. 2011. PMID: 22083723
The only peer-reviewed study in a Danish setting estimated an intervention rate of 2.3 per 1,000 prescriptions. With the introduction of a new tool for registration, we hypothesized that a better estimate could be obtained. ...In the study period, a to …
The only peer-reviewed study in a Danish setting estimated an intervention rate of 2.3 per 1,000 prescriptions. With the introduction …
Excessive anticoagulation with warfarin or phenprocoumon may have multiple causes.
Meegaard PM, Holck LH, Pottegård A, Madsen H, Hallas J. Meegaard PM, et al. Dan Med J. 2012 Feb;59(2):A4383. Dan Med J. 2012. PMID: 22293053
INTRODUCTION: Excessive anticoagulation with vitamin K antagonists is a serious condition with a substantial risk of an adverse outcome. We thus found it of interest to review a large case series to characterize the underlying causes of excessive anticoagulat …
INTRODUCTION: Excessive anticoagulation with vitamin K antagonists is a serious condition with a substantial risk of an advers …
The use of medication against attention deficit hyperactivity disorder in Denmark: a drug use study from a national perspective.
Pottegård A, Bjerregaard BK, Glintborg D, Hallas J, Moreno SI. Pottegård A, et al. Eur J Clin Pharmacol. 2012 Oct;68(10):1443-50. doi: 10.1007/s00228-012-1265-y. Epub 2012 Mar 21. Eur J Clin Pharmacol. 2012. PMID: 22434389
RESULTS: A total of 1,085,090 prescriptions issued to 54,020 persons were identified. The incidence rate was stable in the last 3 years of the study period, and a slightly decreasing incidence rate and a stabilizing prevalence were observed towards the end of …
RESULTS: A total of 1,085,090 prescriptions issued to 54,020 persons were identified. The incidence rate was stable in the last 3 yea …
The use of medication against attention deficit/hyperactivity disorder in Denmark: a drug use study from a patient perspective.
Pottegård A, Bjerregaard BK, Glintborg D, Kortegaard LS, Hallas J, Moreno SI. Pottegård A, et al. Eur J Clin Pharmacol. 2013 Mar;69(3):589-98. doi: 10.1007/s00228-012-1344-0. Epub 2012 Jul 19. Eur J Clin Pharmacol. 2013. PMID: 22811260
METHODS: Using the Danish Registry of Medicinal Product Statistics, we extracted data on 1,085,099 prescriptions for ADHD drugs issued to a total of 54,024 persons in the study period 1 January 1995 to 30 September 2011. ...RESULTS: The mean duration of ADHD treatment was …
METHODS: Using the Danish Registry of Medicinal Product Statistics, we extracted data on 1,085,099 prescriptions for ADHD drugs issued to …
Concurrent use of tramadol and oral vitamin K antagonists and the risk of excessive anticoagulation: a register-based nested case-control study.
Pottegård A, Meegaard PM, Holck LH, Christensen Rd, Madsen H, Hallas J. Pottegård A, et al. Eur J Clin Pharmacol. 2013 Mar;69(3):641-6. doi: 10.1007/s00228-012-1363-x. Epub 2012 Jul 31. Eur J Clin Pharmacol. 2013. PMID: 22847619
DESIGN: The study was designed as a case-control study, nested within users of VKA and with tramadol use as our main exposure. ...RESULTS: A total of 178 patients were included, 30 of which were exposed to tramadol, along with 2643 controls, 114 of which were expose …
DESIGN: The study was designed as a case-control study, nested within users of VKA and with tramadol use as our main exposure. ...RES …
Use of benzodiazepines or benzodiazepine related drugs and the risk of cancer: a population-based case-control study.
Pottegård A, Friis S, Andersen M, Hallas J. Pottegård A, et al. Br J Clin Pharmacol. 2013 May;75(5):1356-64. doi: 10.1111/bcp.12001. Br J Clin Pharmacol. 2013. PMID: 23043261 Free PMC article.
A recent study reported a 35% excess cancer risk among users of hypnotics, including benzodiazepines. METHOD: Using Danish nationwide registers, we conducted a matched case-control study of the association between BZRD and cancer risk. ...In the primary analy
A recent study reported a 35% excess cancer risk among users of hypnotics, including benzodiazepines. METHOD: Using Danish nat
Use of azathioprine for non-thymoma myasthenia and risk of cancer: a nationwide case-control study in Denmark.
Pedersen EG, Pottegård A, Hallas J, Friis S, Hansen K, Jensen PE, Gaist D. Pedersen EG, et al. Eur J Neurol. 2013 Jun;20(6):942-8. doi: 10.1111/ene.12108. Epub 2013 Feb 28. Eur J Neurol. 2013. PMID: 23448676
We observed a slightly elevated OR for cancer overall associated with long-term use of azathioprine (1.22; 95% CI: 0.62-2.40, P = 0.56). ...CONCLUSIONS: Use of azathioprine in patients with non-thymoma MG may be associated with a slightly increased risk of cancer ov …
We observed a slightly elevated OR for cancer overall associated with long-term use of azathioprine (1.22; 95% CI: 0.62-2.40, P = 0.5 …
Assigning exposure duration to single prescriptions by use of the waiting time distribution.
Pottegård A, Hallas J. Pottegård A, et al. Pharmacoepidemiol Drug Saf. 2013 Aug;22(8):803-9. doi: 10.1002/pds.3459. Epub 2013 May 23. Pharmacoepidemiol Drug Saf. 2013. PMID: 23703741
METHODS: We propose a method, based on the waiting time distribution (WTD), which estimates how frequently prevalent users redeem new prescriptions. ...Second, we calculated the cumulative percentage of users that had presented themselves after a given number of day …
METHODS: We propose a method, based on the waiting time distribution (WTD), which estimates how frequently prevalent users redeem new …
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