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In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods.
Poulin P, Kenny JR, Hop CE, Haddad S. Poulin P, et al. J Pharm Sci. 2012 Feb;101(2):838-51. doi: 10.1002/jps.22792. Epub 2011 Oct 18. J Pharm Sci. 2012. PMID: 22009717
Integration of a plasma protein binding factor to the Chemical-Specific Adjustment Factor (CSAF) for facilitating the estimation of uncertainties in interspecies extrapolations when deriving health-based exposure limits for active pharmaceutical ingredients: Investigation of recent drug datasets.
Poulin P, Arnett R. Poulin P, et al. Regul Toxicol Pharmacol. 2017 Dec;91:142-150. doi: 10.1016/j.yrtph.2017.10.026. Epub 2017 Nov 6. Regul Toxicol Pharmacol. 2017. PMID: 29107009
Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen.
Bounakta S, Bteich M, Mantha M, Poulin P, Haddad S. Bounakta S, et al. Among authors: poulin p. Xenobiotica. 2018 Feb;48(2):135-147. doi: 10.1080/00498254.2017.1294276. Epub 2017 Mar 3. Xenobiotica. 2018. PMID: 28277163
Prediction of total hepatic clearance by combining metabolism, transport, and permeability data in the in vitro-in vivo extrapolation methods: emphasis on an apparent fraction unbound in liver for drugs.
Poulin P. Poulin P. J Pharm Sci. 2013 Jul;102(7):2085-95. doi: 10.1002/jps.23562. Epub 2013 Apr 23. J Pharm Sci. 2013. PMID: 23613473
Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data.
Poulin P, Haddad S. Poulin P, et al. J Pharm Sci. 2013 Sep;102(9):3239-51. doi: 10.1002/jps.23502. Epub 2013 Mar 12. J Pharm Sci. 2013. PMID: 23494893
A single-species approach considering additional physiological information for prediction of hepatic clearance of glycoprotein derivate therapeutics.
Poulin P. Poulin P. Clin Pharmacokinet. 2011 Oct;50(10):665-74. doi: 10.2165/11592610-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21895038
Promoting cannabis products to pharmaceutical drugs.
Koltai H, Poulin P, Namdar D. Koltai H, et al. Among authors: poulin p. Eur J Pharm Sci. 2019 Apr 30;132:118-120. doi: 10.1016/j.ejps.2019.02.027. Epub 2019 Mar 7. Eur J Pharm Sci. 2019. PMID: 30851400
The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs.
Bteich M, Poulin P, Haddad S. Bteich M, et al. Among authors: poulin p. Expert Opin Drug Metab Toxicol. 2019 Aug;15(8):633-658. doi: 10.1080/17425255.2019.1640679. Epub 2019 Jul 18. Expert Opin Drug Metab Toxicol. 2019. PMID: 31274340 Review.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance.
Ring BJ, Chien JY, Adkison KK, Jones HM, Rowland M, Jones RD, Yates JW, Ku MS, Gibson CR, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Poulin P. Ring BJ, et al. Among authors: poulin p. J Pharm Sci. 2011 Oct;100(10):4090-110. doi: 10.1002/jps.22552. Epub 2011 May 3. J Pharm Sci. 2011. PMID: 21541938
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
Poulin P, Jones RD, Jones HM, Gibson CR, Rowland M, Chien JY, Ring BJ, Adkison KK, Ku MS, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Yates JW. Poulin P, et al. J Pharm Sci. 2011 Oct;100(10):4127-57. doi: 10.1002/jps.22550. Epub 2011 May 3. J Pharm Sci. 2011. PMID: 21541937
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