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A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells.
Poulsen TT, Pedersen N, Juel H, Poulsen HS. Poulsen TT, et al. Cancer Gene Ther. 2008 Sep;15(9):563-75. doi: 10.1038/cgt.2008.24. Epub 2008 Apr 18. Cancer Gene Ther. 2008. PMID: 18421308
A simple protocol for preparation of a liposomal vesicle with encapsulated plasmid DNA that mediate high accumulation and reporter gene activity in tumor tissue.
Gjetting T, Andresen TL, Christensen CL, Cramer F, Poulsen TT, Poulsen HS. Gjetting T, et al. Results Pharma Sci. 2011 Sep 3;1(1):49-56. doi: 10.1016/j.rinphs.2011.08.001. eCollection 2011 May. Results Pharma Sci. 2011. PMID: 25755981 Free PMC article.
In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection.
Gjetting T, Arildsen NS, Christensen CL, Poulsen TT, Roth JA, Handlos VN, Poulsen HS. Gjetting T, et al. Int J Nanomedicine. 2010 Aug 9;5:371-83. doi: 10.2147/ijn.s10462. Int J Nanomedicine. 2010. PMID: 20957159 Free PMC article.
Pan-HER-An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand-induced EGFR homo- and heterodimers.
Ellebaek S, Brix S, Grandal M, Lantto J, Horak ID, Kragh M, Poulsen TT. Ellebaek S, et al. Among authors: poulsen tt. Int J Cancer. 2016 Nov 1;139(9):2095-105. doi: 10.1002/ijc.30242. Epub 2016 Jul 19. Int J Cancer. 2016. PMID: 27342948 Free article.
Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines.
Cramer F, Christensen CL, Poulsen TT, Badding MA, Dean DA, Poulsen HS. Cramer F, et al. Cancer Gene Ther. 2012 Oct;19(10):675-83. doi: 10.1038/cgt.2012.54. Epub 2012 Aug 17. Cancer Gene Ther. 2012. PMID: 22898898
Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells.
Michaelsen SR, Christensen CL, Sehested M, Cramer F, Poulsen TT, Patterson AV, Poulsen HS. Michaelsen SR, et al. J Gene Med. 2012 Jul;14(7):445-58. doi: 10.1002/jgm.2630. J Gene Med. 2012. PMID: 22576955
Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.
Christensen CL, Gjetting T, Poulsen TT, Cramer F, Roth JA, Poulsen HS. Christensen CL, et al. Clin Cancer Res. 2010 Apr 15;16(8):2308-19. doi: 10.1158/1078-0432.CCR-09-3057. Epub 2010 Apr 6. Clin Cancer Res. 2010. PMID: 20371678 Free PMC article.
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