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In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection.
Gjetting T, Arildsen NS, Christensen CL, Poulsen TT, Roth JA, Handlos VN, Poulsen HS. Gjetting T, et al. Int J Nanomedicine. 2010 Aug 9;5:371-83. doi: 10.2147/ijn.s10462. Int J Nanomedicine. 2010. PMID: 20957159 Free PMC article.
A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells.
Poulsen TT, Pedersen N, Juel H, Poulsen HS. Poulsen TT, et al. Cancer Gene Ther. 2008 Sep;15(9):563-75. doi: 10.1038/cgt.2008.24. Epub 2008 Apr 18. Cancer Gene Ther. 2008. PMID: 18421308
Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines.
Cramer F, Christensen CL, Poulsen TT, Badding MA, Dean DA, Poulsen HS. Cramer F, et al. Cancer Gene Ther. 2012 Oct;19(10):675-83. doi: 10.1038/cgt.2012.54. Epub 2012 Aug 17. Cancer Gene Ther. 2012. PMID: 22898898
Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells.
Michaelsen SR, Christensen CL, Sehested M, Cramer F, Poulsen TT, Patterson AV, Poulsen HS. Michaelsen SR, et al. J Gene Med. 2012 Jul;14(7):445-58. doi: 10.1002/jgm.2630. J Gene Med. 2012. PMID: 22576955
Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.
Christensen CL, Gjetting T, Poulsen TT, Cramer F, Roth JA, Poulsen HS. Christensen CL, et al. Clin Cancer Res. 2010 Apr 15;16(8):2308-19. doi: 10.1158/1078-0432.CCR-09-3057. Epub 2010 Apr 6. Clin Cancer Res. 2010. PMID: 20371678 Free PMC article.
New targets for detection and treatment of small cell lung cancer.
Pedersen N, Pedersen MW, Poulsen TT, Mortensen S, Sørensen SB, Rieneck K, Bovin LF, Poulsen HS. Pedersen N, et al. Chest. 2004 May;125(5 Suppl):154S. doi: 10.1378/chest.125.5_suppl.154s. Chest. 2004. PMID: 15136481 No abstract available.
Replacement and suicide gene therapy for targeted treatment of lung cancer.
Poulsen TT, Pedersen N, Poulsen HS. Poulsen TT, et al. Clin Lung Cancer. 2005 Jan;6(4):227-36. doi: 10.3816/CLC.2005.n.002. Clin Lung Cancer. 2005. PMID: 15694015 Review.
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