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Hypoxia signalling in cancer and approaches to enforce tumour regression.
Pouysségur J, Dayan F, Mazure NM. Pouysségur J, et al. Nature. 2006 May 25;441(7092):437-43. doi: 10.1038/nature04871. Nature. 2006. PMID: 16724055 Review.
Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.
Doyen J, Trastour C, Ettore F, Peyrottes I, Toussant N, Gal J, Ilc K, Roux D, Parks SK, Ferrero JM, Pouysségur J. Doyen J, et al. Among authors: pouyssegur j. Biochem Biophys Res Commun. 2014 Aug 15;451(1):54-61. doi: 10.1016/j.bbrc.2014.07.050. Epub 2014 Jul 21. Biochem Biophys Res Commun. 2014. PMID: 25058459
Redox regulation of the hypoxia-inducible factor.
Pouysségur J, Mechta-Grigoriou F. Pouysségur J, et al. Biol Chem. 2006 Oct-Nov;387(10-11):1337-46. doi: 10.1515/BC.2006.167. Biol Chem. 2006. PMID: 17081104 Review.
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.
Pouysségur J, Volmat V, Lenormand P. Pouysségur J, et al. Biochem Pharmacol. 2002 Sep;64(5-6):755-63. doi: 10.1016/s0006-2952(02)01135-8. Biochem Pharmacol. 2002. PMID: 12213567 Review.
Prevention of this nuclear translocation, by overexpression of a cytoplasmic ERK-docking molecule (inactive MKP3) prevented growth factor-stimulated DNA replication [EMBO J 18 1999 664]. ...Therefore we propose that the nucleus represents a site for ERK action, sequestrati …
Prevention of this nuclear translocation, by overexpression of a cytoplasmic ERK-docking molecule (inactive MKP3) prevented growth factor-st …
Total ERK1/2 activity regulates cell proliferation.
Lefloch R, Pouysségur J, Lenormand P. Lefloch R, et al. Among authors: pouyssegur j. Cell Cycle. 2009 Mar 1;8(5):705-11. doi: 10.4161/cc.8.5.7734. Epub 2009 Mar 29. Cell Cycle. 2009. PMID: 19242111
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noël A, Pouysségur J, Barbry P, Mazure NM, Mari B. Grosso S, et al. Among authors: pouyssegur j. Cell Death Dis. 2013 Mar 14;4(3):e544. doi: 10.1038/cddis.2013.71. Cell Death Dis. 2013. PMID: 23492775 Free PMC article.
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis.
Pelletier J, Dayan F, Durivault J, Ilc K, Pécou E, Pouysségur J, Mazure NM. Pelletier J, et al. Among authors: pouyssegur j. Oncogene. 2012 Jun 14;31(24):2989-3001. doi: 10.1038/onc.2011.471. Epub 2011 Oct 17. Oncogene. 2012. PMID: 22002313
Hypoxic mitochondria: accomplices in resistance.
Mazure NM, Brahimi-Horn MC, Pouysségur J. Mazure NM, et al. Among authors: pouyssegur j. Bull Cancer. 2011 May;98(5):40-6. doi: 10.1684/bdc.2011.1360. Bull Cancer. 2011. PMID: 21609892 Review.
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1alpha.
Formento JL, Berra E, Ferrua B, Magné N, Simos G, Brahimi-Horn C, Pouysségur J, Milano G. Formento JL, et al. Among authors: pouyssegur j. Clin Diagn Lab Immunol. 2005 May;12(5):660-4. doi: 10.1128/CDLI.12.5.660-664.2005. Clin Diagn Lab Immunol. 2005. PMID: 15879029 Free PMC article.
Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway.
Turchi L, Aberdam E, Mazure N, Pouysségur J, Deckert M, Kitajima S, Aberdam D, Virolle T. Turchi L, et al. Among authors: pouyssegur j. Cell Death Differ. 2008 Sep;15(9):1472-80. doi: 10.1038/cdd.2008.74. Epub 2008 May 30. Cell Death Differ. 2008. PMID: 18511933
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