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431 results
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Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.
Chiche J, Brahimi-Horn MC, Pouysségur J. Chiche J, et al. J Cell Mol Med. 2010 Apr;14(4):771-94. doi: 10.1111/j.1582-4934.2009.00994.x. Epub 2009 Dec 8. J Cell Mol Med. 2010. PMID: 20015196 Free PMC article. Review.
Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.
Doyen J, Trastour C, Ettore F, Peyrottes I, Toussant N, Gal J, Ilc K, Roux D, Parks SK, Ferrero JM, Pouysségur J. Doyen J, et al. Biochem Biophys Res Commun. 2014 Aug 15;451(1):54-61. doi: 10.1016/j.bbrc.2014.07.050. Epub 2014 Jul 21. Biochem Biophys Res Commun. 2014. PMID: 25058459
Redox regulation of the hypoxia-inducible factor.
Pouysségur J, Mechta-Grigoriou F. Pouysségur J, et al. Biol Chem. 2006 Oct-Nov;387(10-11):1337-46. doi: 10.1515/BC.2006.167. Biol Chem. 2006. PMID: 17081104 Review.
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.
Bourcier C, Jacquel A, Hess J, Peyrottes I, Angel P, Hofman P, Auberger P, Pouysségur J, Pagès G. Bourcier C, et al. Cancer Res. 2006 Mar 1;66(5):2700-7. doi: 10.1158/0008-5472.CAN-05-3129. Cancer Res. 2006. PMID: 16510590
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity.
Puisségur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouysségur J, Gounon P, Hofman P, Barbry P, Mari B. Puisségur MP, et al. Cell Death Differ. 2011 Mar;18(3):465-78. doi: 10.1038/cdd.2010.119. Epub 2010 Oct 1. Cell Death Differ. 2011. PMID: 20885442 Free PMC article.
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noël A, Pouysségur J, Barbry P, Mazure NM, Mari B. Grosso S, et al. Cell Death Dis. 2013 Mar 14;4(3):e544. doi: 10.1038/cddis.2013.71. Cell Death Dis. 2013. PMID: 23492775 Free PMC article.
The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis.
Pelletier J, Dayan F, Durivault J, Ilc K, Pécou E, Pouysségur J, Mazure NM. Pelletier J, et al. Oncogene. 2012 Jun 14;31(24):2989-3001. doi: 10.1038/onc.2011.471. Epub 2011 Oct 17. Oncogene. 2012. PMID: 22002313
Hypoxic mitochondria: accomplices in resistance.
Mazure NM, Brahimi-Horn MC, Pouysségur J. Mazure NM, et al. Bull Cancer. 2011 May;98(5):40-6. doi: 10.1684/bdc.2011.1360. Bull Cancer. 2011. PMID: 21609892 Review.
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