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Xenobiotic-metabolizing enzymes in human lung.
Zhang JY, Wang Y, Prakash C. Zhang JY, et al. Among authors: prakash c. Curr Drug Metab. 2006 Dec;7(8):939-48. doi: 10.2174/138920006779010575. Curr Drug Metab. 2006. PMID: 17168693 Review.
In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery.
Prakash C, Sharma R, Gleave M, Nedderman A. Prakash C, et al. Curr Drug Metab. 2008 Nov;9(9):952-64. doi: 10.2174/138920008786485209. Curr Drug Metab. 2008. PMID: 18991592
A new quaternary ammonium cysteine analogue as a trapping reagent for reactive metabolites screening.
Penner N, Liu X, Prakash C. Penner N, et al. Among authors: prakash c. Drug Metab Lett. 2014;8(1):36-42. doi: 10.2174/1872312808666140606100739. Drug Metab Lett. 2014. PMID: 24910239
Human radiolabeled mass balance studies: objectives, utilities and limitations.
Penner N, Klunk LJ, Prakash C. Penner N, et al. Among authors: prakash c. Biopharm Drug Dispos. 2009 May;30(4):185-203. doi: 10.1002/bdd.661. Biopharm Drug Dispos. 2009. PMID: 19544285
Disposition of lasofoxifene, a next-generation selective estrogen receptor modulator, in healthy male subjects.
Prakash C, Johnson KA, Gardner MJ. Prakash C, et al. Drug Metab Dispos. 2008 Jul;36(7):1218-26. doi: 10.1124/dmd.108.020404. Epub 2008 Mar 27. Drug Metab Dispos. 2008. PMID: 18372400
Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma.
Prakash C, Shaffer CL, Tremaine LM, Liberman RG, Skipper PL, Flarakos J, Tannenbaum SR. Prakash C, et al. Drug Metab Lett. 2007 Aug;1(3):226-31. doi: 10.2174/187231207781369735. Drug Metab Lett. 2007. PMID: 19356047
High performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometry (HPLC/API/MS/MS) in drug metabolism and toxicology.
Kamel A, Prakash C. Kamel A, et al. Among authors: prakash c. Curr Drug Metab. 2006 Dec;7(8):837-52. doi: 10.2174/138920006779010593. Curr Drug Metab. 2006. PMID: 17168686 Review.
Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.
Yu H, Balani SK, Chen W, Cui D, He L, Humphreys WG, Mao J, Lai WG, Lee AJ, Lim HK, MacLauchlin C, Prakash C, Surapaneni S, Tse S, Upthagrove A, Walsky RL, Wen B, Zeng Z. Yu H, et al. Among authors: prakash c. Drug Metab Dispos. 2015 Apr;43(4):620-30. doi: 10.1124/dmd.114.059345. Epub 2015 Feb 5. Drug Metab Dispos. 2015. PMID: 25655830
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Sharma R, Sun H, Piotrowski DW, Ryder TF, Doran SD, Dai H, Prakash C. Sharma R, et al. Among authors: prakash c. Drug Metab Dispos. 2012 Nov;40(11):2143-61. doi: 10.1124/dmd.112.047316. Epub 2012 Aug 15. Drug Metab Dispos. 2012. PMID: 22896728
CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
Prakash C, Wang W, O'Connell T, Johnson KA. Prakash C, et al. Drug Metab Dispos. 2008 Oct;36(10):2093-103. doi: 10.1124/dmd.108.022897. Epub 2008 Jul 24. Drug Metab Dispos. 2008. PMID: 18653741
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