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Perforin activity at membranes leads to invaginations and vesicle formation.
Praper T, Sonnen AF, Kladnik A, Andrighetti AO, Viero G, Morris KJ, Volpi E, Lunelli L, Dalla Serra M, Froelich CJ, Gilbert RJ, Anderluh G. Praper T, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21016-21. doi: 10.1073/pnas.1107473108. Epub 2011 Dec 15. Proc Natl Acad Sci U S A. 2011. PMID: 22173634 Free PMC article.
Human perforin employs different avenues to damage membranes.
Praper T, Sonnen A, Viero G, Kladnik A, Froelich CJ, Anderluh G, Dalla Serra M, Gilbert RJ. Praper T, et al. J Biol Chem. 2011 Jan 28;286(4):2946-55. doi: 10.1074/jbc.M110.169417. Epub 2010 Oct 2. J Biol Chem. 2011. PMID: 20889983 Free PMC article.