Abstract
Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4'-C-acyloxymethyl-2',3',5'-tri-O-acyl-beta-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose, respectively in a highly selective and efficient manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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Ascomycota / enzymology
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Bridged Bicyclo Compounds / metabolism*
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Candida / enzymology
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Catalysis
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Enzymes, Immobilized / chemistry*
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Fungal Proteins / chemistry*
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Lipase / chemistry*
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Monosaccharides / chemistry*
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Nucleosides / biosynthesis*
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Nucleosides / chemistry
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Thymine / analogs & derivatives*
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Thymine / chemistry
Substances
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4'-C-acyloxymethyl-2',3',5'-tri-O-acyl-beta-L-threo-pentofuranosylthymine
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4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose
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Bridged Bicyclo Compounds
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Enzymes, Immobilized
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Fungal Proteins
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Monosaccharides
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Nucleosides
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Lipase
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Thymine