Pratt WB - Search Results

1

The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase.

Pratt WB. Pratt WB. Annu Rev Pharmacol Toxicol. 1997;37:297-326. doi: 10.1146/annurev.pharmtox.37.1.297. Annu Rev Pharmacol Toxicol. 1997. PMID: 9131255 Review.

2

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Wang AM, et al. Among authors: pratt wb. Nat Chem Biol. 2013 Feb;9(2):112-8. doi: 10.1038/nchembio.1140. Epub 2012 Dec 9. Nat Chem Biol. 2013. PMID: 23222885 Free PMC article.

3

Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors.

Ahsan A, Ramanand SG, Whitehead C, Hiniker SM, Rehemtulla A, Pratt WB, Jolly S, Gouveia C, Truong K, Van Waes C, Ray D, Lawrence TS, Nyati MK. Ahsan A, et al. Among authors: pratt wb. Neoplasia. 2012 Aug;14(8):670-7. doi: 10.1593/neo.12986. Neoplasia. 2012. PMID: 22952420 Free PMC article.

4

Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y. Morishima Y, et al. Among authors: pratt wb. Biochemistry. 2011 Aug 23;50(33):7146-56. doi: 10.1021/bi200751t. Epub 2011 Jul 21. Biochemistry. 2011. PMID: 21755988 Free PMC article.

5

Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.

Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Wang AM, et al. Among authors: pratt wb. J Biol Chem. 2010 May 21;285(21):15714-23. doi: 10.1074/jbc.M109.098806. Epub 2010 Mar 26. J Biol Chem. 2010. PMID: 20348093 Free PMC article.

6

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.

Pratt WB, Morishima Y, Peng HM, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2010 Mar;235(3):278-89. doi: 10.1258/ebm.2009.009250. Exp Biol Med (Maywood). 2010. PMID: 20404045 Free PMC article. Review.

7

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.

Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Pratt WB, et al. Annu Rev Pharmacol Toxicol. 2015;55:353-71. doi: 10.1146/annurev-pharmtox-010814-124332. Epub 2014 Sep 25. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292434 Free PMC article. Review.

8

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation.

Elaimy AL, Ahsan A, Marsh K, Pratt WB, Ray D, Lawrence TS, Nyati MK. Elaimy AL, et al. Among authors: pratt wb. Oncotarget. 2016 Dec 13;7(50):82450-82457. doi: 10.18632/oncotarget.12557. Oncotarget. 2016. PMID: 27738310 Free PMC article.

9

Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.

Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Morishima Y, et al. Among authors: pratt wb. Mol Pharmacol. 2018 Sep;94(3):984-991. doi: 10.1124/mol.118.112516. Epub 2018 Jun 25. Mol Pharmacol. 2018. PMID: 29941666 Free PMC article.

10

A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.

Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2014 Nov;239(11):1405-13. doi: 10.1177/1535370214539444. Epub 2014 Jul 2. Exp Biol Med (Maywood). 2014. PMID: 24990484 Free PMC article. Review.

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