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Precise microinjection into skin using hollow microneedles.
Wang PM, Cornwell M, Hill J, Prausnitz MR. Wang PM, et al. J Invest Dermatol. 2006 May;126(5):1080-7. doi: 10.1038/sj.jid.5700150. J Invest Dermatol. 2006. PMID: 16484988 Free article.
However, little work has been carried out to identify methods to effectively use hollow microneedles for drug delivery. To address this need, we inserted hollow, glass microneedles into hairless rat skin in vivo and human cadaver skin in …
However, little work has been carried out to identify methods to effectively use hollow microneedles for drug delivery. To add …
Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses.
van der Maaden K, Heuts J, Camps M, Pontier M, Terwisscha van Scheltinga A, Jiskoot W, Ossendorp F, Bouwstra J. van der Maaden K, et al. J Control Release. 2018 Jan 10;269:347-354. doi: 10.1016/j.jconrel.2017.11.035. Epub 2017 Nov 22. J Control Release. 2018. PMID: 29174441 Free article.
However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a digitally controlled hollow microneedle injection system (DC-hMN-iSystem) with an ultra-low dead volume was developed to perform …
However, classical intradermal immunization with a hypodermic needle and syringe has several drawbacks. Therefore, in the present study a di …
Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium.
de Groot AM, Du G, Mönkäre J, Platteel ACM, Broere F, Bouwstra JA, Sijts AJAM. de Groot AM, et al. J Control Release. 2017 Nov 28;266:27-35. doi: 10.1016/j.jconrel.2017.09.017. Epub 2017 Sep 14. J Control Release. 2017. PMID: 28917531 Free article.
Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. ...Taken together, we show that PLGA nanoparticle formulation is an excellent delivery system for protein antigen into the skin and that protective cellular immune
Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. ...Taken together, we show tha
Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.
Du G, Hathout RM, Nasr M, Nejadnik MR, Tu J, Koning RI, Koster AJ, Slütter B, Kros A, Jiskoot W, Bouwstra JA, Mönkäre J. Du G, et al. J Control Release. 2017 Nov 28;266:109-118. doi: 10.1016/j.jconrel.2017.09.021. Epub 2017 Sep 21. J Control Release. 2017. PMID: 28943194 Free article.
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely pol …
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein …
Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses.
Schipper P, van der Maaden K, Romeijn S, Oomens C, Kersten G, Jiskoot W, Bouwstra J. Schipper P, et al. J Control Release. 2016 Nov 28;242:141-147. doi: 10.1016/j.jconrel.2016.07.055. Epub 2016 Aug 2. J Control Release. 2016. PMID: 27496634
The purpose of this study was to investigate the effect of various repeated fractional intradermal dosing schedules of inactivated polio vaccine serotype 1 (IPV1) on IPV1-specific IgG responses in rats. By utilizing an applicator that allowed for precisely controlled intra …
The purpose of this study was to investigate the effect of various repeated fractional intradermal dosing schedules of inactivated polio vac …