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Preclinical therapeutic targets in diffuse midline glioma.
Meel MH, Kaspers GJL, Hulleman E. Meel MH, et al. Drug Resist Updat. 2019 May;44:15-25. doi: 10.1016/j.drup.2019.06.001. Epub 2019 Jun 7. Drug Resist Updat. 2019. PMID: 31202081 Free article. Review.
Diffuse midline gliomas (DMG) are rapidly fatal tumors of the midbrain in children, characterized by a diffuse growing pattern and high levels of intrinsic resistance to therapy. ...We here provide an overview of the cellular pathways and tumor-specifi
Diffuse midline gliomas (DMG) are rapidly fatal tumors of the midbrain in children, characterized by a diffuse g
Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas.
Welby JP, Kaptzan T, Wohl A, Peterson TE, Raghunathan A, Brown DA, Gupta SK, Zhang L, Daniels DJ. Welby JP, et al. Front Oncol. 2019 Feb 27;9:92. doi: 10.3389/fonc.2019.00092. eCollection 2019. Front Oncol. 2019. PMID: 30873381 Free PMC article.
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. ...These models
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse
Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
Wierzbicki K, Ravi K, Franson A, Bruzek A, Cantor E, Harris M, Homan MJ, Marini BL, Kawakibi AR, Ravindran R, Teodoro R, Yadav VN, Koschmann C. Wierzbicki K, et al. Curr Oncol Rep. 2020 Feb 6;22(2):19. doi: 10.1007/s11912-020-0877-0. Curr Oncol Rep. 2020. PMID: 32030483 Review.
PURPOSE OF REVIEW: H3K27M is a frequent histone mutation within diffuse midline gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO classification system created a specific category of "Diffuse Midline Glioma
PURPOSE OF REVIEW: H3K27M is a frequent histone mutation within diffuse midline gliomas and is associated with a dismal …
Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy.
Graham MS, Mellinghoff IK. Graham MS, et al. Int J Mol Sci. 2020 Sep 29;21(19):7193. doi: 10.3390/ijms21197193. Int J Mol Sci. 2020. PMID: 33003625 Free PMC article. Review.
Specific hallmark oncogenic histone mutations within pediatric malignant gliomas divide these tumors into subgroups with different neuroanatomic and chronologic predilections. In this review, we will summarize the characteristic molecular alterations of pediatric high-grad …
Specific hallmark oncogenic histone mutations within pediatric malignant gliomas divide these tumors into subgroups with different ne …
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