Development of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primates.
Yang X, Morris SM, Gearhart JM, Ruark CD, Paule MG, Slikker W Jr, Mattison DR, Vitiello B, Twaddle NC, Doerge DR, Young JF, Fisher JW.
Yang X, et al.
PLoS One. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101. eCollection 2014.
PLoS One. 2014.
PMID: 25184666
Free PMC article.
The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been deve …
The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect …