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Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status.
Li M, Zhao P, Pan Y, Wagner C. Li M, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):82-89. doi: 10.1002/psp4.12260. Epub 2017 Nov 23. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29168611 Free PMC article. Review.
A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether physiologically based pharmacokinetic (PBPK) modeling could be prospectively used to predict clinical foo …
A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether …
Food, gastrointestinal pH, and models of oral drug absorption.
Abuhelwa AY, Williams DB, Upton RN, Foster DJ. Abuhelwa AY, et al. Eur J Pharm Biopharm. 2017 Mar;112:234-248. doi: 10.1016/j.ejpb.2016.11.034. Epub 2016 Nov 30. Eur J Pharm Biopharm. 2017. PMID: 27914234 Review.
This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the various absorption models that are used to describe/pr …
This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal …
Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug-Food Interactions: Recommendations for Improving Predictive Performance of Low Confidence Food Effect Models.
Wagner C, Kesisoglou F, Pepin XJH, Parrott N, Emami Riedmaier A. Wagner C, et al. AAPS J. 2021 Jun 17;23(4):85. doi: 10.1208/s12248-021-00601-0. AAPS J. 2021. PMID: 34142242
The use of physiologically based pharmacokinetic models has gained importance and is nowadays a standard tool for food effect predictions at preclinical and clinical stages in the pharmaceutical industry. This manuscript is part of …
The use of physiologically based pharmacokinetic models has gained importance and is nowadays a standard tool fo …
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
Riedmaier AE, DeMent K, Huckle J, Bransford P, Stillhart C, Lloyd R, Alluri R, Basu S, Chen Y, Dhamankar V, Dodd S, Kulkarni P, Olivares-Morales A, Peng CC, Pepin X, Ren X, Tran T, Tistaert C, Heimbach T, Kesisoglou F, Wagner C, Parrott N. Riedmaier AE, et al. AAPS J. 2020 Sep 27;22(6):123. doi: 10.1208/s12248-020-00508-2. AAPS J. 2020. PMID: 32981010 Free PMC article.
The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinicall …
The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of oral …
Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection.
Gajewska M, Blumenstein L, Kourentas A, Mueller-Zsigmondy M, Lorenzo S, Sinn A, Velinova M, Heimbach T. Gajewska M, et al. AAPS J. 2020 Oct 18;22(6):134. doi: 10.1208/s12248-020-00511-7. AAPS J. 2020. PMID: 33070288 Clinical Trial.
A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral alpha-specific class I phosphatidylinositol-3-kinase (PI3K) inhibitor, was established to simulate oral absorption and plasma pharmacokinetics of hea …
A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral alpha-specific class I …
Personalise vitamin D3 using physiologically based pharmacokinetic modelling.
Huang Z, You T. Huang Z, et al. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):723-734. doi: 10.1002/psp4.12640. Epub 2021 Jun 3. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33960722 Free PMC article.
We collated vitamin D(3) and 25(OH)D(3) plasma PK data from reported clinical trials and developed a physiologically-based pharmacokinetic (PBPK) model to appropriately recapitulate training data. ...WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE? Our mo …
We collated vitamin D(3) and 25(OH)D(3) plasma PK data from reported clinical trials and developed a physiologically-based …
Physiologically Based Pharmacokinetic Modeling Approach to Identify the Drug-Drug Interaction Mechanism of Nifedipine and a Proton Pump Inhibitor, Omeprazole.
Le Merdy M, Tan ML, Sun D, Ni Z, Lee SC, Babiskin A, Zhao L. Le Merdy M, et al. Eur J Drug Metab Pharmacokinet. 2021 Jan;46(1):41-51. doi: 10.1007/s13318-020-00649-x. Eur J Drug Metab Pharmacokinet. 2021. PMID: 33064292
RESULTS: The developed PBPK model properly described the pharmacokinetics of nifedipine and predicted the inhibitory effect of multiple-dose omeprazole on CYP3A4 activity. With the incorporation of the physiologic effect of omeprazole on …
RESULTS: The developed PBPK model properly described the pharmacokinetics of nifedipine and predicted the inhibitory …
Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups.
Liu XI, van den Anker JN, Burckart GJ, Dallmann A. Liu XI, et al. J Clin Pharmacol. 2021 Jun;61 Suppl 1:S94-S107. doi: 10.1002/jcph.1845. J Clin Pharmacol. 2021. PMID: 34185902
Age-related changes in many parameters affecting drug absorption remain poorly characterized. The objective of this study was to apply physiologically based pharmacokinetic (PBPK) models in pediatric patients to investigate the absorption and …
Age-related changes in many parameters affecting drug absorption remain poorly characterized. The objective of this study was to appl …
On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet.
Kushwah V, Arora S, Tamás Katona M, Modhave D, Fröhlich E, Paudel A. Kushwah V, et al. Pharmaceutics. 2021 Feb 20;13(2):283. doi: 10.3390/pharmaceutics13020283. Pharmaceutics. 2021. PMID: 33672439 Free PMC article.
The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II drug, from the orally administered commercial immediate-release tablet (Xarelto IR) using physiologically based pharmacokinetic (PBPK) and conven …
The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II drug, from the orally admi …
Physiologically-Based Pharmacokinetic Modeling to Predict the Clinical Efficacy of the Coadministration of Lopinavir and Ritonavir against SARS-CoV-2.
Thakur A, Tan SPF, Chan JCY. Thakur A, et al. Clin Pharmacol Ther. 2020 Dec;108(6):1176-1184. doi: 10.1002/cpt.2014. Epub 2020 Oct 6. Clin Pharmacol Ther. 2020. PMID: 32767755 Free PMC article.
We built a physiologically-based pharmacokinetic model of lopinavir/ritonavir in white and Chinese populations. Our aim was to perform pharmacokinetic/pharmacodynamic correlations by comparing simulated free plasma and lung concentration …
We built a physiologically-based pharmacokinetic model of lopinavir/ritonavir in white and Chinese populations. …
31 results