Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 1
2010 1
2011 1
2012 3
2013 1
2014 4
2015 1
2016 1
2017 4
2018 2
2019 1
2020 4
2021 7
2022 4
2023 3
2024 1
2025 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

37 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Food, gastrointestinal pH, and models of oral drug absorption.
Abuhelwa AY, Williams DB, Upton RN, Foster DJ. Abuhelwa AY, et al. Eur J Pharm Biopharm. 2017 Mar;112:234-248. doi: 10.1016/j.ejpb.2016.11.034. Epub 2016 Nov 30. Eur J Pharm Biopharm. 2017. PMID: 27914234 Review.
This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the various absorption models that are used to describe/pr
This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal …
Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status.
Li M, Zhao P, Pan Y, Wagner C. Li M, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):82-89. doi: 10.1002/psp4.12260. Epub 2017 Nov 23. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29168611 Free PMC article. Review.
A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether physiologically based pharmacokinetic (PBPK) modeling could be prospectively used to predict clinical foo
A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether …
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
Riedmaier AE, DeMent K, Huckle J, Bransford P, Stillhart C, Lloyd R, Alluri R, Basu S, Chen Y, Dhamankar V, Dodd S, Kulkarni P, Olivares-Morales A, Peng CC, Pepin X, Ren X, Tran T, Tistaert C, Heimbach T, Kesisoglou F, Wagner C, Parrott N. Riedmaier AE, et al. AAPS J. 2020 Sep 27;22(6):123. doi: 10.1208/s12248-020-00508-2. AAPS J. 2020. PMID: 32981010 Free PMC article.
The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinicall …
The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of oral …
Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug-Food Interactions: Recommendations for Improving Predictive Performance of Low Confidence Food Effect Models.
Wagner C, Kesisoglou F, Pepin XJH, Parrott N, Emami Riedmaier A. Wagner C, et al. AAPS J. 2021 Jun 17;23(4):85. doi: 10.1208/s12248-021-00601-0. AAPS J. 2021. PMID: 34142242
The use of physiologically based pharmacokinetic models has gained importance and is nowadays a standard tool for food effect predictions at preclinical and clinical stages in the pharmaceutical industry. This manuscript is part of …
The use of physiologically based pharmacokinetic models has gained importance and is nowadays a standard tool fo …
Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups.
Liu XI, van den Anker JN, Burckart GJ, Dallmann A. Liu XI, et al. J Clin Pharmacol. 2021 Jun;61 Suppl 1:S94-S107. doi: 10.1002/jcph.1845. J Clin Pharmacol. 2021. PMID: 34185902
Age-related changes in many parameters affecting drug absorption remain poorly characterized. The objective of this study was to apply physiologically based pharmacokinetic (PBPK) models in pediatric patients to investigate the absorption and …
Age-related changes in many parameters affecting drug absorption remain poorly characterized. The objective of this study was to appl …
Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues.
Liu Y, Sprando RL. Liu Y, et al. J Appl Toxicol. 2023 Apr;43(4):589-598. doi: 10.1002/jat.4409. Epub 2022 Nov 3. J Appl Toxicol. 2023. PMID: 36272108
At the present time, there is limited information available on the pharmacokinetics of cannabinoids in humans. Since pharmacokinetic profiles are important in understanding the pharmacological and toxicological effects at the target sites, physiologically
At the present time, there is limited information available on the pharmacokinetics of cannabinoids in humans. Since pharmacokinet
Physiologically Based Pharmacokinetic Modeling Approach to Identify the Drug-Drug Interaction Mechanism of Nifedipine and a Proton Pump Inhibitor, Omeprazole.
Le Merdy M, Tan ML, Sun D, Ni Z, Lee SC, Babiskin A, Zhao L. Le Merdy M, et al. Eur J Drug Metab Pharmacokinet. 2021 Jan;46(1):41-51. doi: 10.1007/s13318-020-00649-x. Eur J Drug Metab Pharmacokinet. 2021. PMID: 33064292
The purpose of this study is to apply a physiologically based pharmacokinetic (PBPK) modeling approach to investigate the DDI mechanism for an immediate release formulation of nifedipine with omeprazole. ...RESULTS: The developed PBPK model prop …
The purpose of this study is to apply a physiologically based pharmacokinetic (PBPK) modeling approach to invest …
Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection.
Gajewska M, Blumenstein L, Kourentas A, Mueller-Zsigmondy M, Lorenzo S, Sinn A, Velinova M, Heimbach T. Gajewska M, et al. AAPS J. 2020 Oct 18;22(6):134. doi: 10.1208/s12248-020-00511-7. AAPS J. 2020. PMID: 33070288 Clinical Trial.
A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral alpha-specific class I phosphatidylinositol-3-kinase (PI3K) inhibitor, was established to simulate oral absorption and plasma pharmacokinetics of hea …
A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral alpha-specific class I …
Meta-Analysis of Food Effect on Oral Absorption of Efflux Transporter Substrate Drugs: Does Delayed Gastric Emptying Influence Drug Transport Kinetics?
Sharma S, Prasad B. Sharma S, et al. Pharmaceutics. 2021 Jul 7;13(7):1035. doi: 10.3390/pharmaceutics13071035. Pharmaceutics. 2021. PMID: 34371727 Free PMC article.
Food is one of the major factors that affect oral drug absorption by influencing drug properties (e.g., solubility and dissolution rate) and physiological factors (e.g., metabolism and transport across the gastrointestinal tract). ...Moreover, a
Food is one of the major factors that affect oral drug absorption by influencing drug properties (e.g., solubili
Personalise vitamin D(3) using physiologically based pharmacokinetic modelling.
Huang Z, You T. Huang Z, et al. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):723-734. doi: 10.1002/psp4.12640. Epub 2021 Jun 3. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33960722 Free PMC article.
We collated vitamin D(3) and 25(OH)D(3) plasma PK data from reported clinical trials and developed a physiologically-based pharmacokinetic (PBPK) model to appropriately recapitulate training data. ...WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE? Our mo
We collated vitamin D(3) and 25(OH)D(3) plasma PK data from reported clinical trials and developed a physiologically-based
37 results