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Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.
Premkumar A, Wilson L, Ewart GD, Gage PW. Premkumar A, et al. FEBS Lett. 2004 Jan 16;557(1-3):99-103. doi: 10.1016/s0014-5793(03)01453-4. FEBS Lett. 2004. PMID: 14741348
A 63 residue peptide, p7, encoded by hepatitis C virus was synthesised and tested for ion channel activity in lipid bilayer membranes. ...Hexamethylene amiloride, a drug previously shown to block ion channels formed by Vpu encoded by HIV-1, blocked channels formed b
A 63 residue peptide, p7, encoded by hepatitis C virus was synthesised and tested for ion channel activity in lipid bilayer membranes
Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication.
Premkumar A, Dong X, Haqshenas G, Gage PW, Gowans EJ. Premkumar A, et al. Antivir Ther. 2006;11(3):289-95. Antivir Ther. 2006. PMID: 16759044
A chemically synthesized peptide representing the C-terminal subunit (p13-C) of the p13 protein of GB virus B (GBV-B), the most closely related virus to hepatitis C virus (HCV) showed ion channel activity in artificial lipid bilayers. The channels had a variable con
A chemically synthesized peptide representing the C-terminal subunit (p13-C) of the p13 protein of GB virus B (GBV-B), the most close
Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels.
Premkumar A, Horan CR, Gage PW. Premkumar A, et al. J Membr Biol. 2005 Mar;204(1):33-8. doi: 10.1007/s00232-005-0744-9. J Membr Biol. 2005. PMID: 16007501
A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to
A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (D
An amino-acid substitution in the influenza-B NB protein affects ion-channel gating.
Premkumar A, Ewart GD, Cox GB, Gage PW. Premkumar A, et al. J Membr Biol. 2004 Feb 1;197(3):135-43. doi: 10.1007/s00232-004-0648-0. J Membr Biol. 2004. PMID: 15042345
The effects of site-directed mutations in NB, a protein encoded by the influenza B virus that has been shown to form cation-selective ion channels at pH 6.0, were studied on ion channel characteristics in artificial lipid bilayers. ...
The effects of site-directed mutations in NB, a protein encoded by the influenza B virus that has been shown to form cation-selective …
Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.
Piller SC, Ewart GD, Premkumar A, Cox GB, Gage PW. Piller SC, et al. Among authors: premkumar a. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):111-5. doi: 10.1073/pnas.93.1.111. Proc Natl Acad Sci U S A. 1996. PMID: 8552585 Free PMC article.
A small (96-aa) protein, virus protein R (Vpr), of human immunodeficiency virus type 1 contains one hydrophobic segment that could form a membrane-spanning helix. ...The effects of potential and antibodies on channel activity are consistent with a model in wh
A small (96-aa) protein, virus protein R (Vpr), of human immunodeficiency virus type 1 contains one hydrophobic segment that could fo
Ion channels formed by NB, an influenza B virus protein.
Sunstrom NA, Premkumar LS, Premkumar A, Ewart G, Cox GB, Gage PW. Sunstrom NA, et al. Among authors: premkumar ls, premkumar a. J Membr Biol. 1996 Mar;150(2):127-32. doi: 10.1007/s002329900037. J Membr Biol. 1996. PMID: 8661776
An antibody to a peptide mimicking the 25 residues at the C-terminal end of NB, and amantadine at high concentration (2-3 mM), both depressed ion channel activity. Ion channels had a variable conductance, the lowest conductance observed being approximately 10 picosi …
An antibody to a peptide mimicking the 25 residues at the C-terminal end of NB, and amantadine at high concentration (2-3 mM), both d …
Preoperative Use of Higher-Strength Opioids has a Dose-Dependent Association with Reoperations after Lumbar Decompression and Interbody Fusion Surgery.
Samuel AM, Lovecchio FC, Premkumar A, Louie PK, Vaishnav AS, Iyer S, McAnany SJ, Albert TJ, Gang CH, Qureshi SA. Samuel AM, et al. Among authors: premkumar a. Spine (Phila Pa 1976). 2020 Oct 19. doi: 10.1097/BRS.0000000000003751. Online ahead of print. Spine (Phila Pa 1976). 2020. PMID: 33079910
Analysis of Hip and Knee Reconstruction Questions on the Orthopedic In-Training Examination.
Premkumar A, Lebrun DG, Shen TS, Ellsworth BK, Bostrom MPG, Cross MB. Premkumar A, et al. J Arthroplasty. 2020 Sep 18:S0883-5403(20)31013-5. doi: 10.1016/j.arth.2020.09.018. Online ahead of print. J Arthroplasty. 2020. PMID: 33036844
Birth Behind Bars: The Need for Labor Support in the Incarcerated Population.
Dahl CM, Geynisman-Tan JM, Premkumar A. Dahl CM, et al. Among authors: premkumar a. Obstet Gynecol. 2020 Oct 8. doi: 10.1097/AOG.0000000000004119. Online ahead of print. Obstet Gynecol. 2020. PMID: 33030860
Correction to: At the US Epicenter of the COVID-19 Pandemic, an Orthopedic Residency Program Reorganizes.
Morse KW, Wessel LE, Premkumar A, James EW, Anatone AJ, Barth K, Bovonratwet P, Jordan Y, Retzky J, Suhardi V, Thacher R, Uppstrom T, Yang B, Bido J, Carey E, Defrancesco C, Elbuluk A, Lebrun D, Ondeck N, Pompeu Y, Schimizzi G, Shafi K, Apostolakos JM, Barber LA, Brusalis CM, Driscoll DA, Ellsworth B, Langhans M, Shen T, Wright-Chisem J, Conti M, Eliasberg C, Goeb Y, Henry J, Lin KM, Lovecchio F, Samuel A, Dvorzhinskiy A, Goodbody C, Gruskay J, Heaps B, Hurwit D, Kahlenberg C, Rauck R, Steinhaus M, Bostrom M, Cross M, Fabricant PD, Felix K, Green D, Kim HJ, Leali A, Memnon CM, O'Brasky M, Ranawat A, Robbins L, Nwachukwu BU, Fufa DT. Morse KW, et al. Among authors: premkumar a. HSS J. 2020 Sep 15:1-2. doi: 10.1007/s11420-020-09780-6. Online ahead of print. HSS J. 2020. PMID: 32952466 Free PMC article.
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