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Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD. Kuestner RE, et al. Among authors: presnell s. J Immunol. 2007 Oct 15;179(8):5462-73. doi: 10.4049/jimmunol.179.8.5462. J Immunol. 2007. PMID: 17911633 Free PMC article.
IL-28, IL-29 and their class II cytokine receptor IL-28R.
Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM. Sheppard P, et al. Among authors: presnell s. Nat Immunol. 2003 Jan;4(1):63-8. doi: 10.1038/ni873. Epub 2002 Dec 2. Nat Immunol. 2003. PMID: 12469119
Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, Brender T, Okada S, Lum K, West J, Kuijper JL, Ardourel D, Franke S, Lockwood L, Vu T, Frank A, Appleby MW, Wolf A, Reardon B, Hamacher NB, Stevens B, Lewis P, Lewis KB, Gilbertson DG, Lantry M, Julien SH, Ostrander C, Chan C, Byrnes-Blake K, Brody J, Presnell S, Meengs B, Levin SD, Snavely M. Mabry R, et al. Among authors: presnell s. Protein Eng Des Sel. 2010 Mar;23(3):115-27. doi: 10.1093/protein/gzp073. Epub 2009 Dec 18. Protein Eng Des Sel. 2010. PMID: 20022918
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.
Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC. Xu W, et al. Among authors: presnell sr. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9511-6. doi: 10.1073/pnas.171303198. Epub 2001 Jul 31. Proc Natl Acad Sci U S A. 2001. PMID: 11481447 Free PMC article.
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA. Dillon SR, et al. Among authors: presnell sr. Nat Immunol. 2004 Jul;5(7):752-60. doi: 10.1038/ni1084. Epub 2004 Jun 6. Nat Immunol. 2004. PMID: 15184896
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D. Parrish-Novak J, et al. Among authors: presnell sr. Nature. 2000 Nov 2;408(6808):57-63. doi: 10.1038/35040504. Nature. 2000. PMID: 11081504
A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo.
Mabry R, Gilbertson DG, Frank A, Vu T, Ardourel D, Ostrander C, Stevens B, Julien S, Franke S, Meengs B, Brody J, Presnell S, Hamacher NB, Lantry M, Wolf A, Bukowski T, Rosler R, Yen C, Anderson-Haley M, Brasel K, Pan Q, Franklin H, Thompson P, Dodds M, Underwood S, Peterson S, Sivakumar PV, Snavely M. Mabry R, et al. Among authors: presnell s. MAbs. 2010 Jan-Feb;2(1):20-34. doi: 10.4161/mabs.2.1.10498. Epub 2010 Jan 2. MAbs. 2010. PMID: 20065654 Free PMC article.
Cloning and characterization of a novel class I cytokine receptor.
Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF. Sprecher CA, et al. Among authors: presnell sr. Biochem Biophys Res Commun. 1998 May 8;246(1):82-90. doi: 10.1006/bbrc.1998.8576. Biochem Biophys Res Commun. 1998. PMID: 9600072
Cloning and characterization of human protease-activated receptor 4.
Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC. Xu WF, et al. Among authors: presnell sr. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6642-6. doi: 10.1073/pnas.95.12.6642. Proc Natl Acad Sci U S A. 1998. PMID: 9618465 Free PMC article.
138 results