Prestwich GD - Search Results

1

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.

Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS, Hinshaw JC, Garnier P, Prestwich GD, Leonardson A, Garrett-Engele P, Rush CM, Bard M, Schimmack G, Phillips JW, Roberts CJ, Shoemaker DD. Lum PY, et al. Among authors: prestwich gd. Cell. 2004 Jan 9;116(1):121-37. doi: 10.1016/s0092-8674(03)01035-3. Cell. 2004. PMID: 14718172 Free article.

2

Oxidosqualene cyclase inhibitors as antimicrobial agents.

Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD. Hinshaw JC, et al. Among authors: prestwich gd. J Med Chem. 2003 Sep 25;46(20):4240-3. doi: 10.1021/jm034126t. J Med Chem. 2003. PMID: 13678402

3

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.

McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD. McIntyre TM, et al. Among authors: prestwich gd. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):131-6. doi: 10.1073/pnas.0135855100. Epub 2002 Dec 26. Proc Natl Acad Sci U S A. 2003. PMID: 12502787 Free PMC article.

4

Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists.

Davies SS, Pontsler AV, Marathe GK, Harrison KA, Murphy RC, Hinshaw JC, Prestwich GD, Hilaire AS, Prescott SM, Zimmerman GA, McIntyre TM. Davies SS, et al. Among authors: prestwich gd. J Biol Chem. 2001 May 11;276(19):16015-23. doi: 10.1074/jbc.M100878200. Epub 2001 Feb 26. J Biol Chem. 2001. PMID: 11279149 Free article.

5

Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex.

Li X, Rivas MP, Fang M, Marchena J, Mehrotra B, Chaudhary A, Feng L, Prestwich GD, Bankaitis VA. Li X, et al. Among authors: prestwich gd. J Cell Biol. 2002 Apr 1;157(1):63-77. doi: 10.1083/jcb.200201037. Epub 2002 Mar 26. J Cell Biol. 2002. PMID: 11916983 Free PMC article.

6

Antigenic prenylated peptide conjugates and polyclonal antibodies to detect protein prenylation.

Liu XH, Suh DY, Call J, Prestwich GD. Liu XH, et al. Among authors: prestwich gd. Bioconjug Chem. 2004 Mar-Apr;15(2):270-7. doi: 10.1021/bc0342027. Bioconjug Chem. 2004. PMID: 15025522

7

Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.

Stach D, Zheng YF, Perez AL, Oehlschlager AC, Abe I, Prestwich GD, Hartman PG. Stach D, et al. Among authors: prestwich gd. J Med Chem. 1997 Jan 17;40(2):201-9. doi: 10.1021/jm960483a. J Med Chem. 1997. PMID: 9003518

8

Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase.

Abe I, Zheng YF, Prestwich GD. Abe I, et al. Among authors: prestwich gd. J Enzyme Inhib. 1998 Sep;13(6):385-98. doi: 10.3109/14756369809020544. J Enzyme Inhib. 1998. PMID: 9825303 Review.

9

Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase.

Sen SE, Prestwich GD. Sen SE, et al. Among authors: prestwich gd. J Med Chem. 1989 Sep;32(9):2152-8. doi: 10.1021/jm00129a022. J Med Chem. 1989. PMID: 2769687

10

Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution.

Dang T, Prestwich GD. Dang T, et al. Among authors: prestwich gd. Chem Biol. 2000 Aug;7(8):643-9. doi: 10.1016/s1074-5521(00)00003-x. Chem Biol. 2000. PMID: 11048954

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