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Flagellar activation of epithelial signaling.
Prince A. Prince A. Am J Respir Cell Mol Biol. 2006 May;34(5):548-51. doi: 10.1165/rcmb.2006-0022SF. Epub 2006 Jan 26. Am J Respir Cell Mol Biol. 2006. PMID: 16439803 Review.
Mucosal epithelial cells are an important component of the innate immune system forming a physical and immunologic barrier to inhaled bacteria. ...The complexities of flagella and flagellin structures, how these bacterial components initiate host signaling and their potent …
Mucosal epithelial cells are an important component of the innate immune system forming a physical and immunologic barrier to inhaled …
Adhesins and receptors of Pseudomonas aeruginosa associated with infection of the respiratory tract.
Prince A. Prince A. Microb Pathog. 1992 Oct;13(4):251-60. doi: 10.1016/0882-4010(92)90035-m. Microb Pathog. 1992. PMID: 1363702 Review.
Substantial progress has been made in defining a number of Pseudomonas adhesins which may be involved in the pathogenesis of respiratory infection. ...The organisms do not invade the bronchial tissue, but remain in the airways forming a biofilm with associated micro …
Substantial progress has been made in defining a number of Pseudomonas adhesins which may be involved in the pathogenesis of respirat …
Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.
Cacalano G, Kays M, Saiman L, Prince A. Cacalano G, et al. Among authors: prince a. J Clin Invest. 1992 Jun;89(6):1866-74. doi: 10.1172/JCI115791. J Clin Invest. 1992. PMID: 1601994 Free PMC article.
The pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis (CF) is a complex process attributed to specific characteristics of both the host and the infecting organism. ...
The pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis (CF) is a complex process attributed to specific characterist …
Comparison of adherence of Pseudomonas aeruginosa to respiratory epithelial cells from cystic fibrosis patients and healthy subjects.
Saiman L, Cacalano G, Gruenert D, Prince A. Saiman L, et al. Among authors: prince a. Infect Immun. 1992 Jul;60(7):2808-14. doi: 10.1128/IAI.60.7.2808-2814.1992. Infect Immun. 1992. PMID: 1612746 Free PMC article.
The effect of piliation and exoproduct expression on the adherence of Pseudomonas aeruginosa to respiratory epithelial monolayers.
Saiman L, Ishimoto K, Lory S, Prince A. Saiman L, et al. Among authors: prince a. J Infect Dis. 1990 Mar;161(3):541-8. doi: 10.1093/infdis/161.3.541. J Infect Dis. 1990. PMID: 1968936
A pil- mutant PAK/NP, constructed by gene replacement, demonstrated low levels of attachment (3.8% of the inoculum adherent compared with 7% for the wild-type strain PAK), suggesting that other adhesins are functional. ...P1 produced 10-fold more proteinase than did PA1244
A pil- mutant PAK/NP, constructed by gene replacement, demonstrated low levels of attachment (3.8% of the inoculum adherent compared
Pseudomonas cepacia adherence to respiratory epithelial cells is enhanced by Pseudomonas aeruginosa.
Saiman L, Cacalano G, Prince A. Saiman L, et al. Among authors: prince a. Infect Immun. 1990 Aug;58(8):2578-84. doi: 10.1128/IAI.58.8.2578-2584.1990. Infect Immun. 1990. PMID: 1983811 Free PMC article.
PAO1 exoproducts had a marked effect in enhancing the ability of the P. cepacia strains to adhere to the epithelial monolayers. A PAO1 supernatant increased the binding of 249 by eightfold and that of 715j by fourfold. Thus, there appears to be a synergistic …
PAO1 exoproducts had a marked effect in enhancing the ability of the P. cepacia strains to adhere to the epithelial monolayers. A
Cross-reactivity of Pseudomonas aeruginosa antipilin monoclonal antibodies with heterogeneous strains of P. aeruginosa and Pseudomonas cepacia.
Saiman L, Sadoff J, Prince A. Saiman L, et al. Among authors: prince a. Infect Immun. 1989 Sep;57(9):2764-70. doi: 10.1128/IAI.57.9.2764-2770.1989. Infect Immun. 1989. PMID: 2569448 Free PMC article.
Prevention of colonization and subsequent infection would be a useful therapeutic strategy. The pili (fimbriae) of P. aeruginosa are a potential vaccine antigen, as they have been implicated in binding to respiratory epithelium and appear to have limited antigenic d …
Prevention of colonization and subsequent infection would be a useful therapeutic strategy. The pili (fimbriae) of P. aeruginosa are …
Binding of Pseudomonas aeruginosa to respiratory epithelial cells from patients with various mutations in the cystic fibrosis transmembrane regulator.
Zar H, Saiman L, Quittell L, Prince A. Zar H, et al. Among authors: prince a. J Pediatr. 1995 Feb;126(2):230-3. doi: 10.1016/s0022-3476(95)70549-x. J Pediatr. 1995. PMID: 7531240
Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8.
DiMango E, Zar HJ, Bryan R, Prince A. DiMango E, et al. Among authors: prince a. J Clin Invest. 1995 Nov;96(5):2204-10. doi: 10.1172/JCI118275. J Clin Invest. 1995. PMID: 7593606 Free PMC article.
A piliated, nonflagellated strain was also associated with decreased binding and a diminished level of IL-8 production when compared to wild-type organisms. ...In addition, the IL-8 response was four-fold higher in a cystic fibrosis cell line compared with it
A piliated, nonflagellated strain was also associated with decreased binding and a diminished level of IL-8 production when co
Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface.
Imundo L, Barasch J, Prince A, Al-Awqati Q. Imundo L, et al. Among authors: prince a. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3019-23. doi: 10.1073/pnas.92.7.3019. Proc Natl Acad Sci U S A. 1995. PMID: 7708767 Free PMC article.
We found that polarized CF bronchial and pancreatic epithelia bound P. aeruginosa in a reversible and dose-dependent manner. ...These results show that the tetrasaccharide of aGM1 is a receptor for P. aeruginosa and S. aureus and that its increased abundance in the …
We found that polarized CF bronchial and pancreatic epithelia bound P. aeruginosa in a reversible and dose-dependent manner. ...These …
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