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LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
Pellas TC, Colombo C, Fryer LR, Pastor G, Haston W, Raychaudhuri A, Kotyuk B, Greenspan PD, Healy C, DiPasquale G. Pellas TC, et al. J Pharmacol Toxicol Methods. 1993 Nov;30(3):137-42. doi: 10.1016/1056-8719(93)90036-e. J Pharmacol Toxicol Methods. 1993. PMID: 8305713
This phenomenon is applied in the neutropenia model whereby circulating blood neutrophil counts prior to and after intravenous infusion of LTB4 are compared. Kinetics of LTB4-induced neutrophil responses are determined through the use of a Technicon H*1 automated bl …
This phenomenon is applied in the neutropenia model whereby circulating blood neutrophil counts prior to and after intravenous infusi …
Is pentobarbital appropriate for basal anesthesia in the working rat heart model?
Oguchi T, Kashimoto S, Yamaguchi T, Nakamura T, Kumazawa T. Oguchi T, et al. J Pharmacol Toxicol Methods. 1993 Feb;29(1):37-43. doi: 10.1016/1056-8719(93)90049-k. J Pharmacol Toxicol Methods. 1993. PMID: 8481560
After control perfusion, whole-heart ischemia was induced by one-way aortic valve for 15 min followed by reperfusion for 30 min. During preischemic control period, cardiac output (CO) and left ventricular dP/dT maximum (LV dP/dT max) in the isoflurane group were significan …
After control perfusion, whole-heart ischemia was induced by one-way aortic valve for 15 min followed by reperfusion for 30 min. Duri …