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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1994 10
1995 11
1996 40
1997 44
1998 42
1999 52
2000 66
2001 90
2002 106
2003 111
2004 122
2005 96
2006 8
2007 10
2008 13
2009 22
2010 28
2011 18
2012 21
2013 26
2014 36
2015 45
2016 40
2017 26
2018 39
2019 30
2020 34
2021 38
2022 31
2023 26
2024 14

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1,191 results

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Page 1
PRKCD as a potential therapeutic target for chronic obstructive pulmonary disease.
Li S, Huang Q, Zhou D, He B. Li S, et al. Int Immunopharmacol. 2022 Dec;113(Pt A):109374. doi: 10.1016/j.intimp.2022.109374. Epub 2022 Oct 21. Int Immunopharmacol. 2022. PMID: 36279664 Review.
Recently, PRKCD has been reported to play an important role in the pathogenesis of COPD. However, the mechanisms of PRKCD on COPD are not fully elucidated. AIM: In this review, we will discuss the roles and mechanisms of PRKCD involved in the development of C …
Recently, PRKCD has been reported to play an important role in the pathogenesis of COPD. However, the mechanisms of PRKCD on C …
Phenotypic Variability in PRKCD: a Review of the Literature.
Jefferson L, Ramanan AV, Jolles S, Bernatoniene J, Mathieu AL, Belot A, Roderick MR. Jefferson L, et al. J Clin Immunol. 2023 Nov;43(8):1692-1705. doi: 10.1007/s10875-023-01579-4. Epub 2023 Oct 5. J Clin Immunol. 2023. PMID: 37794137 Review.
GAK and PRKCD kinases regulate basal mitophagy.
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Simonsen A. Munson MJ, et al. Autophagy. 2022 Feb;18(2):467-469. doi: 10.1080/15548627.2021.2015154. Epub 2022 Jan 9. Autophagy. 2022. PMID: 35001811 Free PMC article.
Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act as positive regulators of PRKN-independent mitophagy. We demonstrate that PRKCD is l …
Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determ …
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin-proteasome-mediated degradation of PRKCD.
Sun L, Chen Y, Xia L, Wang J, Zhu J, Li J, Wang K, Shen K, Zhang D, Zhang G, Shi T, Chen W. Sun L, et al. Oncogene. 2023 Dec;42(49):3619-3632. doi: 10.1038/s41388-023-02873-6. Epub 2023 Oct 20. Oncogene. 2023. PMID: 37864033
TRIM69 knockdown had the opposite effects. Mechanistically, TRIM69 interacted with PRKCD through its B-box domain and catalyzed the K48-linked polyubiquitination of PRKCD. Moreover, TRIM69 inhibited BDNF production in a PRKCD-dependent manner. Importantly, ov …
TRIM69 knockdown had the opposite effects. Mechanistically, TRIM69 interacted with PRKCD through its B-box domain and catalyzed the K …
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A. Munson MJ, et al. Nat Commun. 2021 Oct 20;12(1):6101. doi: 10.1038/s41467-021-26331-7. Nat Commun. 2021. PMID: 34671015 Free PMC article.
We identify Cyclin G-associated kinase (GAK) and Protein Kinase C Delta (PRKCD) as regulators of PRKN-independent mitophagy, with both being dispensable for PRKN-dependent mitophagy and starvation-induced autophagy. We demonstrate that the kinase activity of both GAK and …
We identify Cyclin G-associated kinase (GAK) and Protein Kinase C Delta (PRKCD) as regulators of PRKN-independent mitophagy, with bot …
PRKCD/PKCdelta contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy.
Zhang D, Xu X, Dong Z. Zhang D, et al. Autophagy. 2017 Mar 4;13(3):631-632. doi: 10.1080/15548627.2016.1269990. Epub 2017 Jan 6. Autophagy. 2017. PMID: 28059582 Free PMC article.
Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress U …
Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell de …
Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
Deng Y, Hou Z, Li Y, Yi M, Wu Y, Zheng Y, Yang F, Zhong G, Hao Q, Zhai Z, Wang M, Ma X, Kang H, Ji F, Dong C, Liu H, Dai Z. Deng Y, et al. Cell Commun Signal. 2024 Feb 12;22(1):115. doi: 10.1186/s12964-024-01487-z. Cell Commun Signal. 2024. PMID: 38347536 Free PMC article.
We mapped the kinases activity of different subtypes of breast cancer and identified PRKCD_pY313 was upregulated in TNBC cell lines. Gain-of-function assay revealed that PRKCD_pY313 facilitated the proliferation, enhanced invasion, accelerated metastasis, increased …
We mapped the kinases activity of different subtypes of breast cancer and identified PRKCD_pY313 was upregulated in TNBC cell lines. …
Genetic association of PRKCD and CARD9 polymorphisms with Vogt-Koyanagi-Harada disease in the Chinese Han population.
Zhou C, Cai S, Xie Y, Zeng Z, Zhang J, Su G, Wu Q, Ye X, Cao Q, Yang P, Hu J. Zhou C, et al. Hum Genomics. 2023 Feb 13;17(1):9. doi: 10.1186/s40246-023-00459-7. Hum Genomics. 2023. PMID: 36782298 Free PMC article.
BACKGROUND: Protein kinase C delta (PRKCD) and caspase recruitment domain family member 9 (CARD9) are genes involved in B and T cell activation, and cytokine production, which are vital mechanisms underlying autoimmune disease development. This study aimed to explore the a …
BACKGROUND: Protein kinase C delta (PRKCD) and caspase recruitment domain family member 9 (CARD9) are genes involved in B and T cell …
Loss of PKCdelta/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.
Singh G, O-Sullivan I, Natarajan Anbazhagan A, Ranjan K C, Farooqui Z, Ma K, Wang J, Mwale F, Votta-Velis G, Bruce B, Ronald Kahn C, van Wijnen AJ, Im HJ. Singh G, et al. Gene. 2024 Jan 30;893:147920. doi: 10.1016/j.gene.2023.147920. Epub 2023 Oct 25. Gene. 2024. PMID: 37890601
The present study investigated the functional role of PKCdelta in OA pain sensation. OA was surgically induced in control (Prkcd(fl/fl)), global- (Prkcd(fl/fl); ROSA(CreERT2)), and sensory neuron-specific conditional knockout (cKO) mice (Prkcd(fl/fl;) NaV1.8/ …
The present study investigated the functional role of PKCdelta in OA pain sensation. OA was surgically induced in control (Prkcd(fl/f …
1,191 results