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Manipulation of coacervate droplets with an electric field.
Agrawal A, Douglas JF, Tirrell M, Karim A. Agrawal A, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203483119. doi: 10.1073/pnas.2203483119. Epub 2022 Aug 4. Proc Natl Acad Sci U S A. 2022. PMID: 35925890 Free PMC article.
Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating.
Oyama K, Zeeb V, Yamazawa T, Kurebayashi N, Kobirumaki-Shimozawa F, Murayama T, Oyamada H, Noguchi S, Inoue T, Inoue YU, Nishino I, Harada Y, Fukuda N, Ishiwata S, Suzuki M. Oyama K, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201286119. doi: 10.1073/pnas.2201286119. Epub 2022 Aug 4. Proc Natl Acad Sci U S A. 2022. PMID: 35925888 Free PMC article.
An anti-CTLA-4 heavy chain-only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile.
Gan X, Shan Q, Li H, Janssens R, Shen Y, He Y, Chen F, van Haperen R, Drabek D, Li J, Zhang Y, Zhao J, Qin B, Jheng MJ, Chen V, Wang J, Rong Y, Grosveld F. Gan X, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2200879119. doi: 10.1073/pnas.2200879119. Epub 2022 Aug 4. Proc Natl Acad Sci U S A. 2022. PMID: 35925889 Free PMC article.