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Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence.
Lorenz N, Loh JM, Moreland NJ, Proft T. Lorenz N, et al. J Microbiol Methods. 2017 Mar;134:58-61. doi: 10.1016/j.mimet.2017.01.010. Epub 2017 Jan 21. J Microbiol Methods. 2017. PMID: 28115206
Identification and characterization of novel superantigens from Streptococcus pyogenes.
Proft T, Moffatt SL, Berkahn CJ, Fraser JD. Proft T, et al. J Exp Med. 1999 Jan 4;189(1):89-102. doi: 10.1084/jem.189.1.89. J Exp Med. 1999. PMID: 9874566 Free PMC article.
All toxins, except rSPE-G, were active on murine T cells, but with reduced potency. Binding to a human B-lymphoblastoid line was shown to be zinc dependent with high binding affinity of 15-65 nM. ...The most common targets for the novel SAgs were human Vbeta2.1- and Vbeta4 …
All toxins, except rSPE-G, were active on murine T cells, but with reduced potency. Binding to a human B-lymphoblastoid line was show …
Superantigens - powerful modifiers of the immune system.
Fraser J, Arcus V, Kong P, Baker E, Proft T. Fraser J, et al. Mol Med Today. 2000 Mar;6(3):125-32. doi: 10.1016/s1357-4310(99)01657-3. Mol Med Today. 2000. PMID: 10689316 Review.
Superantigens are powerful microbial toxins that activate the immune system by binding to class II major histocompatibility complex and T-cell receptor molecules. ...Their mode of action and variation around the common theme of over-stimulating T cells, provides a r …
Superantigens are powerful microbial toxins that activate the immune system by binding to class II major histocompatibility complex and T
Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes.
Arcus VL, Proft T, Sigrell JA, Baker HM, Fraser JD, Baker EN. Arcus VL, et al. J Mol Biol. 2000 May 26;299(1):157-68. doi: 10.1006/jmbi.2000.3725. J Mol Biol. 2000. PMID: 10860729
They are implicated in a range of human pathologies associated with bacterial infection whose symptoms result from SAg-mediated stimulation of a large number (2-20%) of T-cells. At the molecular level, bacterial SAgs bind to major histocompatability class II (MHC-II) molec …
They are implicated in a range of human pathologies associated with bacterial infection whose symptoms result from SAg-mediated stimulation …
Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.
Proft T, Arcus VL, Handley V, Baker EN, Fraser JD. Proft T, et al. J Immunol. 2001 Jun 1;166(11):6711-9. doi: 10.4049/jimmunol.166.11.6711. J Immunol. 2001. PMID: 11359827
SPE-I preferably stimulates T cells bearing the Vbeta18.1 TCR, which is not targeted by any other known SAG: SPE-J almost exclusively stimulates Vbeta2.1 T cells, a Vbeta that is targeted by several other streptococcal SAgs, suggesting a specific role for this T
SPE-I preferably stimulates T cells bearing the Vbeta18.1 TCR, which is not targeted by any other known SAG: SPE-J almost exclusively …
Two novel superantigens found in both group A and group C Streptococcus.
Proft T, Webb PD, Handley V, Fraser JD. Proft T, et al. Infect Immun. 2003 Mar;71(3):1361-9. doi: 10.1128/iai.71.3.1361-1369.2003. Infect Immun. 2003. PMID: 12595453 Free PMC article.
The most common targets for both toxins were human Vbeta1.1 expressing T cells. Seroconversion against SPE-L and SPE-M was observed in healthy blood donors, suggesting that the toxins are expressed in vivo. ...
The most common targets for both toxins were human Vbeta1.1 expressing T cells. Seroconversion against SPE-L and SPE-M was observed i …
Superantigens and streptococcal toxic shock syndrome.
Proft T, Sriskandan S, Yang L, Fraser JD. Proft T, et al. Emerg Infect Dis. 2003 Oct;9(10):1211-8. doi: 10.3201/eid0910.030042. Emerg Infect Dis. 2003. PMID: 14609454 Free PMC article.
Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity.
Yang LP, Eriksson BK, Harrington Z, Curtis N, Lang S, Currie BJ, Fraser JD, Proft T. Yang LP, et al. Med Microbiol Immunol. 2006 Mar;195(1):37-43. doi: 10.1007/s00430-005-0245-6. Epub 2005 Jun 30. Med Microbiol Immunol. 2006. PMID: 15988608
Superantigens (SAgs) from group A streptococcus (GAS) are potent T cell mitogens, and have been suggested to play a role in severe streptococcal disease. ...Patients sera were tested for their ability to neutralize T cell mitogenicity of recombinant streptococcal SA …
Superantigens (SAgs) from group A streptococcus (GAS) are potent T cell mitogens, and have been suggested to play a role in severe st …
Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome.
Yang L, Thomas M, Woodhouse A, Martin D, Fraser JD, Proft T. Yang L, et al. J Clin Microbiol. 2005 Jul;43(7):3570-3. doi: 10.1128/JCM.43.7.3570-3573.2005. J Clin Microbiol. 2005. PMID: 16000510 Free PMC article.
Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome.
Schrage B, Duan G, Yang LP, Fraser JD, Proft T. Schrage B, et al. Clin Infect Dis. 2006 Sep 15;43(6):743-6. doi: 10.1086/507037. Epub 2006 Aug 8. Clin Infect Dis. 2006. PMID: 16912949
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