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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1992 2
1993 9
1995 2
1996 3
1997 1
1998 5
1999 7
2000 7
2001 7
2002 6
2003 14
2004 9
2005 6
2006 35
2007 61
2008 70
2009 77
2010 94
2011 130
2012 109
2013 112
2014 114
2015 104
2016 152
2017 139
2018 164
2019 146
2020 153
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2022 138
2023 127
2024 100

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2,006 results

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Page 1
Progranulin as a therapeutic target in neurodegenerative diseases.
Rhinn H, Tatton N, McCaughey S, Kurnellas M, Rosenthal A. Rhinn H, et al. Trends Pharmacol Sci. 2022 Aug;43(8):641-652. doi: 10.1016/j.tips.2021.11.015. Epub 2022 Jan 15. Trends Pharmacol Sci. 2022. PMID: 35039149 Free article. Review.
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. ...
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and m …
Progranulin in neurodegenerative dementia.
Wang XM, Zeng P, Fang YY, Zhang T, Tian Q. Wang XM, et al. J Neurochem. 2021 Jul;158(2):119-137. doi: 10.1111/jnc.15378. Epub 2021 May 28. J Neurochem. 2021. PMID: 33930186 Free article. Review.
Long-term or severe lack of protective factors is important in the pathogenesis of neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly in neurons and microglia, has various neuroprotective effects such as anti-inflammatory effects, promot …
Long-term or severe lack of protective factors is important in the pathogenesis of neurodegenerative dementia. Progranulin (PGRN), a …
Progranulin Regulates Inflammation and Tumor.
Liu C, Li J, Shi W, Zhang L, Liu S, Lian Y, Liang S, Wang H. Liu C, et al. Antiinflamm Antiallergy Agents Med Chem. 2020;19(2):88-102. doi: 10.2174/1871523018666190724124214. Antiinflamm Antiallergy Agents Med Chem. 2020. PMID: 31339079 Free PMC article. Review.
Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycopr …
Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator …
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia.
Simon MJ, Logan T, DeVos SL, Di Paolo G. Simon MJ, et al. Trends Cell Biol. 2023 Apr;33(4):324-339. doi: 10.1016/j.tcb.2022.09.006. Epub 2022 Oct 13. Trends Cell Biol. 2023. PMID: 36244875 Free article. Review.
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN), were identified in patients with frontotemporal lobar degeneration (FTLD) almost two decades ago and are generally linked to reduced PGRN protein expression levels. ...
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN), were identified in patients with frontotemporal …
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV Jr, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Zhang J, et al. Nature. 2020 Dec;588(7838):459-465. doi: 10.1038/s41586-020-2709-7. Epub 2020 Aug 31. Nature. 2020. PMID: 32866962 Free PMC article.
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsufficiency in the gene encoding progranulin(1,2). However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use sing …
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsuffic …
Progranulin is essential for bone homeostasis and immunology.
Chen Q, Wu Z, Xie L. Chen Q, et al. Ann N Y Acad Sci. 2022 Dec;1518(1):58-68. doi: 10.1111/nyas.14905. Epub 2022 Sep 30. Ann N Y Acad Sci. 2022. PMID: 36177883 Review.
Intercellular communication or crosstalk between immune and skeletal cells is considered a crucial element in bone homeostasis modulation. Progranulin (PGRN) is an autocrine growth factor that is structured as beads-on-a-string and participates in multiple pathophysiologic …
Intercellular communication or crosstalk between immune and skeletal cells is considered a crucial element in bone homeostasis modulation. …
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.
Gillett DA, Wallings RL, Uriarte Huarte O, Tansey MG. Gillett DA, et al. J Neuroinflammation. 2023 Nov 30;20(1):286. doi: 10.1186/s12974-023-02965-w. J Neuroinflammation. 2023. PMID: 38037070 Free PMC article. Review.
BACKGROUND: Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and lysosomal storage disorders (LSDs). ...
BACKGROUND: Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fro …
Targeting Progranulin as an Immuno-Neurology Therapeutic Approach.
Boylan MA, Pincetic A, Romano G, Tatton N, Kenkare-Mitra S, Rosenthal A. Boylan MA, et al. Int J Mol Sci. 2023 Nov 3;24(21):15946. doi: 10.3390/ijms242115946. Int J Mol Sci. 2023. PMID: 37958929 Free PMC article. Review.
Loss-of-function (LOF) mutations causing decreased levels of progranulin (PGRN), an immune regulatory protein, lead to dysfunctional microglia and are associated with multiple neurodegenerative diseases, including frontotemporal dementia caused by the progranulin ge …
Loss-of-function (LOF) mutations causing decreased levels of progranulin (PGRN), an immune regulatory protein, lead to dysfunctional …
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.
Kurnellas M, Mitra A, Schwabe T, Paul R, Arrant AE, Roberson ED, Ward M, Yeh F, Long H, Rosenthal A. Kurnellas M, et al. J Transl Med. 2023 Jun 15;21(1):387. doi: 10.1186/s12967-023-04251-y. J Transl Med. 2023. PMID: 37322482 Free PMC article.
BACKGROUND: Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). ...
BACKGROUND: Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the de …
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Low RLY, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, Sun EW, Hsiao-Nakamoto J, Rajendra Y, Lexa KW, Srivastava DB, van Lengerich B, Wang J, Robles-Colmenares Y, Kim DJ, Duque J, Lenser M, Earr TK, Nguyen H, Chau R, Tsogtbaatar B, Ravi R, Skuja LL, Solanoy H, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Dennis MS, Kariolis MS, Monroe KM, Przybyla L, Sanchez PE, Meisner R, Diaz D, Henne KR, Watts RJ, Henry AG, Gunasekaran K, Astarita G, Suh JH, Lewcock JW, DeVos SL, Di Paolo G. Logan T, et al. Cell. 2021 Sep 2;184(18):4651-4668.e25. doi: 10.1016/j.cell.2021.08.002. Epub 2021 Aug 26. Cell. 2021. PMID: 34450028 Free PMC article.
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. ...
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with …
2,006 results