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Why is big Pharma getting out of antibacterial drug discovery?
Projan SJ. Projan SJ. Curr Opin Microbiol. 2003 Oct;6(5):427-30. doi: 10.1016/j.mib.2003.08.003. Curr Opin Microbiol. 2003. PMID: 14572532 Review.
Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent.
Projan SJ. Projan SJ. Pharmacotherapy. 2000 Sep;20(9 Pt 2):219S-223S; discussion 224S-228S. doi: 10.1592/phco.20.14.219s.35046. Pharmacotherapy. 2000. PMID: 11001329
Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system.
Alksne LE, Burgio P, Hu W, Feld B, Singh MP, Tuckman M, Petersen PJ, Labthavikul P, McGlynn M, Barbieri L, McDonald L, Bradford P, Dushin RG, Rothstein D, Projan SJ. Alksne LE, et al. Antimicrob Agents Chemother. 2000 Jun;44(6):1418-27. doi: 10.1128/aac.44.6.1418-1427.2000. Antimicrob Agents Chemother. 2000. PMID: 10817687 Free PMC article.
Recent developments in tetracycline antibiotics.
Sum PE, Sum FW, Projan SJ. Sum PE, et al. Curr Pharm Des. 1998 Apr;4(2):119-32. Curr Pharm Des. 1998. PMID: 10197036 Review.
Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis.
Dunman PM, Mounts W, McAleese F, Immermann F, Macapagal D, Marsilio E, McDougal L, Tenover FC, Bradford PA, Petersen PJ, Projan SJ, Murphy E. Dunman PM, et al. J Clin Microbiol. 2004 Sep;42(9):4275-83. doi: 10.1128/JCM.42.9.4275-4283.2004. J Clin Microbiol. 2004. PMID: 15365023 Free PMC article.
Antibacterial drug discovery: is it all downhill from here?
Projan SJ, Shlaes DM. Projan SJ, et al. Clin Microbiol Infect. 2004 Nov;10 Suppl 4:18-22. doi: 10.1111/j.1465-0691.2004.1006.x. Clin Microbiol Infect. 2004. PMID: 15522036 Review.
Bacterial virulence as a target for antimicrobial chemotherapy.
Alksne LE, Projan SJ. Alksne LE, et al. Curr Opin Biotechnol. 2000 Dec;11(6):625-36. doi: 10.1016/s0958-1669(00)00155-5. Curr Opin Biotechnol. 2000. PMID: 11102800 Review.
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA. McAleese F, et al. Antimicrob Agents Chemother. 2005 May;49(5):1865-71. doi: 10.1128/AAC.49.5.1865-1871.2005. Antimicrob Agents Chemother. 2005. PMID: 15855508 Free PMC article.
Small molecules for small minds? The case for biologic pharmaceuticals.
Projan SJ, Gill D, Lu Z, Herrmann SH. Projan SJ, et al. Expert Opin Biol Ther. 2004 Aug;4(8):1345-50. doi: 10.1517/14712598.4.8.1345. Expert Opin Biol Ther. 2004. PMID: 15268667 Review.
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