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Prospective derivation of a living organoid biobank of colorectal cancer patients.
van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, van Sluis P, Li VS, Seepo S, Sekhar Pedamallu C, Cibulskis K, Carter SL, McKenna A, Lawrence MS, Lichtenstein L, Stewart C, Koster J, Versteeg R, van Oudenaarden A, Saez-Rodriguez J, Vries RG, Getz G, Wessels L, Stratton MR, McDermott U, Meyerson M, Garnett MJ, Clevers H. van de Wetering M, et al. Cell. 2015 May 7;161(4):933-45. doi: 10.1016/j.cell.2015.03.053. Cell. 2015. PMID: 25957691 Free PMC article.
In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. We report the establishment of tumor organoid cultures from 20 consecutive colorectal carcinoma (CRC) patients …
In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue …
Patient-derived organoids from metastatic colorectal cancer mirror tumor heterogeneity and predict patient survival and drug sensitivity.
Kryeziu K, Klokkerud SK, Totland MZ, Moosavi SH, Reims HM, Bergsland CH, Eilertsen IA, Smeby J, Lassen K, Lundesgaard KK, Syversveen T, Brændengen M, Nesbakken A, Guren TK, Yaqub S, Sveen A, Lothe RA. Kryeziu K, et al. Cell Rep Med. 2026 Jun 16;7(6):102840. doi: 10.1016/j.xcrm.2026.102840. Epub 2026 May 28. Cell Rep Med. 2026. PMID: 42208542 Free PMC article.
This study reports the pharmacogenomic analysis of tumor heterogeneity in a living biobank of 213 organoids derived from liver metastases of 102 patients with metastatic colorectal cancer. Successful organoid establishment r …
This study reports the pharmacogenomic analysis of tumor heterogeneity in a living biobank of 213 organoids derived …