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The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.
Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt BJ, Hales BJ, Walker ML, Hollams E, Bochkov YA, Grindle K, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M. Teo SM, et al. Cell Host Microbe. 2015 May 13;17(5):704-15. doi: 10.1016/j.chom.2015.03.008. Epub 2015 Apr 9. Cell Host Microbe. 2015. PMID: 25865368 Free PMC article.
We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, capturing both the viral and bacterial communities and documenting all incidents of ARIs. ...Transient incursions of Streptococcus, Mor …
We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, ca …
Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations.
Martínez-Rivera C, Crespo A, Pinedo-Sierra C, García-Rivero JL, Pallarés-Sanmartín A, Marina-Malanda N, Pascual-Erquicia S, Padilla A, Mayoralas-Alises S, Plaza V, López-Viña A, Picado C. Martínez-Rivera C, et al. Respir Med. 2018 Feb;135:22-28. doi: 10.1016/j.rmed.2017.12.013. Epub 2018 Jan 3. Respir Med. 2018. PMID: 29414449 Free article.
METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecretion was clinically classified into two severity categories: daily sputum production and frequent expectoration but not every day. Cl …
METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecre …
Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life.
Latzin P, Frey U, Roiha HL, Baldwin DN, Regamey N, Strippoli MP, Zwahlen M, Kuehni CE; Swiss Paediatric Respiratory Research Group. Latzin P, et al. Pediatr Pulmonol. 2007 Jan;42(1):41-50. doi: 10.1002/ppul.20542. Pediatr Pulmonol. 2007. PMID: 17123315
Respiratory symptoms are common in infancy. Nevertheless, few prospective birth cohort studies have studied the epidemiology of respiratory symptoms in normal infants. ...In a prospective population-based birth cohort, we
Respiratory symptoms are common in infancy. Nevertheless, few prospective birth cohort studies have studied the
Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.
Martinez CH, Murray S, Barr RG, Bleecker E, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Krishnan JA, Lazarus SC, Leidy NK, O'Neal W, Martinez FJ, Paine R 3rd, Rennard SI, Tashkin DP, Woodruff PG, Han MK; Subpopulations and Intermediate Outcome Measures in COPD Study Investigators. Martinez CH, et al. Ann Am Thorac Soc. 2017 May;14(5):636-642. doi: 10.1513/AnnalsATS.201610-815OC. Ann Am Thorac Soc. 2017. PMID: 28459622 Free PMC article.
After testing sensitivity and specificity of different scores for the first four questions to predict any 1-year follow-up exacerbation, we selected cutpoints of 0-6 as representing a low burden of symptoms versus scores of 7 or higher as representing a high …
After testing sensitivity and specificity of different scores for the first four questions to predict any 1-year follow-up exa …
Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhood.
Devulapalli CS. Devulapalli CS. Clin Respir J. 2008 Oct;2(4):247-8. doi: 10.1111/j.1752-699X.2008.00064.x. Clin Respir J. 2008. PMID: 20298343
INTRODUCTION: The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear. AIMS: This study was conducted (i) to determine how often ICS were used for treatment of obstructive airways disease (OAD) in early childhood; (ii) to …
INTRODUCTION: The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear. AIMS: This study was …
A prospective study of the impact of air pollution on respiratory symptoms and infections in infants.
Stern G, Latzin P, Röösli M, Fuchs O, Proietti E, Kuehni C, Frey U. Stern G, et al. Am J Respir Crit Care Med. 2013 Jun 15;187(12):1341-8. doi: 10.1164/rccm.201211-2008OC. Am J Respir Crit Care Med. 2013. PMID: 23594341
OBJECTIVES: To assess the association of air pollution with frequency and severity of respiratory symptoms and infections measured weekly in healthy infants. METHODS: In a prospective birth cohort of 366 infants of unselected mothers, respira
OBJECTIVES: To assess the association of air pollution with frequency and severity of respiratory symptoms and i …
Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age.
Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL. Guerra S, et al. Am J Respir Crit Care Med. 2004 Jan 1;169(1):70-6. doi: 10.1164/rccm.200304-499OC. Epub 2003 Oct 2. Am J Respir Crit Care Med. 2004. PMID: 14525803
The odds of developing recurrent wheezing (assessed by questionnaire) in the first year of life were up to 4.5 times higher for children in the lowest quartile of IFNgamma production at 3 months (p = 0.0005) and 3.2 times higher for children in the low …
The odds of developing recurrent wheezing (assessed by questionnaire) in the first year of life were up to 4.5 t …
Moderately preterm children have more respiratory problems during their first 5 years of life than children born full term.
Vrijlandt EJ, Kerstjens JM, Duiverman EJ, Bos AF, Reijneveld SA. Vrijlandt EJ, et al. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1234-40. doi: 10.1164/rccm.201211-2070OC. Am J Respir Crit Care Med. 2013. PMID: 23525931 Clinical Trial.
METHODS: Prospective cohort study. OUTCOME VARIABLES: number of rehospitalizations caused by respiratory problems, prevalence of respiratory symptoms determined by ISAAC Questionnaires, and factors associated with respiratory symptoms
METHODS: Prospective cohort study. OUTCOME VARIABLES: number of rehospitalizations caused by respiratory problems, prevalence …
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes.
Garcia-Aymerich J, Gómez FP, Benet M, Farrero E, Basagaña X, Gayete À, Paré C, Freixa X, Ferrer J, Ferrer A, Roca J, Gáldiz JB, Sauleda J, Monsó E, Gea J, Barberà JA, Agustí À, Antó JM; PAC-COPD Study Group. Garcia-Aymerich J, et al. Thorax. 2011 May;66(5):430-7. doi: 10.1136/thx.2010.154484. Epub 2010 Dec 21. Thorax. 2011. PMID: 21177668 Free article.
METHODS: To identify and validate COPD subtypes, 342 subjects hospitalised for the first time because of a COPD exacerbation were recruited. Three months after discharge, when clinically stable, symptoms and quality of life, lung function, exercise capacity, …
METHODS: To identify and validate COPD subtypes, 342 subjects hospitalised for the first time because of a COPD exacerbation were rec …
Lung-volume reduction surgery as an alternative or bridging procedure to lung transplantation.
Tutic M, Lardinois D, Imfeld S, Korom S, Boehler A, Speich R, Bloch KE, Russi EW, Weder W. Tutic M, et al. Ann Thorac Surg. 2006 Jul;82(1):208-13; discussion 213. doi: 10.1016/j.athoracsur.2006.02.004. Ann Thorac Surg. 2006. PMID: 16798216
Survival analysis was performed by use of the Kaplan-Meier method. RESULTS: All the functional variables significantly improved after LVRS and peaked within the first year. ...CONCLUSIONS: Lung-volume reduction surgery can significantly improve symptoms
Survival analysis was performed by use of the Kaplan-Meier method. RESULTS: All the functional variables significantly improved after …
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