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2003 1
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Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life.
Latzin P, Frey U, Roiha HL, Baldwin DN, Regamey N, Strippoli MP, Zwahlen M, Kuehni CE; Swiss Paediatric Respiratory Research Group. Latzin P, et al. Pediatr Pulmonol. 2007 Jan;42(1):41-50. doi: 10.1002/ppul.20542. Pediatr Pulmonol. 2007. PMID: 17123315
The aim of this study was to prospectively obtain reliable data on incidence, severity, and determinants of common respiratory symptoms (including cough and wheeze) in normal infants and to determine factors associated with these …
The aim of this study was to prospectively obtain reliable data on incidence, severity, and determinants of comm …
Prevalence and determinants of persistent symptoms after infection with SARS-CoV-2: protocol for an observational cohort study (LongCOVID-study).
Mutubuki EN, van der Maaden T, Leung KY, Wong A, Tulen AD, de Bruijn S, Haverman L, Knoop H, Franz E, van Hoek AJ, van den Wijngaard CC. Mutubuki EN, et al. BMJ Open. 2022 Jul 1;12(7):e062439. doi: 10.1136/bmjopen-2022-062439. BMJ Open. 2022. PMID: 35777877 Free PMC article.
However, knowledge regarding the nature and risk factors for developing persisting symptoms is still limited. Hence, in this study, we aim to determine the prevalence, severity, risk factors and impact on quality of life of persisting symptoms i …
However, knowledge regarding the nature and risk factors for developing persisting symptoms is still limited. Hence, in this study, w …
The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.
Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, Holt BJ, Hales BJ, Walker ML, Hollams E, Bochkov YA, Grindle K, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M. Teo SM, et al. Cell Host Microbe. 2015 May 13;17(5):704-15. doi: 10.1016/j.chom.2015.03.008. Epub 2015 Apr 9. Cell Host Microbe. 2015. PMID: 25865368 Free PMC article.
We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, capturing both the viral and bacterial communities and documenting all incidents of ARIs. ...Transient incursions of Streptococcus, Mor …
We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, ca …
A prospective study of the impact of air pollution on respiratory symptoms and infections in infants.
Stern G, Latzin P, Röösli M, Fuchs O, Proietti E, Kuehni C, Frey U. Stern G, et al. Am J Respir Crit Care Med. 2013 Jun 15;187(12):1341-8. doi: 10.1164/rccm.201211-2008OC. Am J Respir Crit Care Med. 2013. PMID: 23594341
OBJECTIVES: To assess the association of air pollution with frequency and severity of respiratory symptoms and infections measured weekly in healthy infants. METHODS: In a prospective birth cohort of 366 infants of unselected mothers, respira …
OBJECTIVES: To assess the association of air pollution with frequency and severity of respiratory symptoms and i …
Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations.
Martínez-Rivera C, Crespo A, Pinedo-Sierra C, García-Rivero JL, Pallarés-Sanmartín A, Marina-Malanda N, Pascual-Erquicia S, Padilla A, Mayoralas-Alises S, Plaza V, López-Viña A, Picado C. Martínez-Rivera C, et al. Respir Med. 2018 Feb;135:22-28. doi: 10.1016/j.rmed.2017.12.013. Epub 2018 Jan 3. Respir Med. 2018. PMID: 29414449 Free article.
METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecretion was clinically classified into two severity categories: daily sputum production and frequent expectoration but not every day. Cl …
METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecre …
Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.
Martinez CH, Murray S, Barr RG, Bleecker E, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Krishnan JA, Lazarus SC, Leidy NK, O'Neal W, Martinez FJ, Paine R 3rd, Rennard SI, Tashkin DP, Woodruff PG, Han MK; Subpopulations and Intermediate Outcome Measures in COPD Study Investigators. Martinez CH, et al. Ann Am Thorac Soc. 2017 May;14(5):636-642. doi: 10.1513/AnnalsATS.201610-815OC. Ann Am Thorac Soc. 2017. PMID: 28459622 Free PMC article.
After testing sensitivity and specificity of different scores for the first four questions to predict any 1-year follow-up exacerbation, we selected cutpoints of 0-6 as representing a low burden of symptoms versus scores of 7 or higher as representing a high …
After testing sensitivity and specificity of different scores for the first four questions to predict any 1-year follow-up exa …
Study protocol: the ear-nose-throat (ENT) prospective international cohort of patients with primary ciliary dyskinesia (EPIC-PCD).
Goutaki M, Lam YT, Alexandru M, Anagiotos A, Armengot M, Bequignon E, Boon M, Burgess A, Coste A, Emiralioglu N, Erdem E, Haarman EG, Harris A, Hool SL, Karadag B, Kim S, Latzin P, Lorent N, Ozcelik U, Reula A, Roehmel J, van Gogh C, Yiallouros P, Zappe SM; EPIC-PCD team; Papon JF. Goutaki M, et al. BMJ Open. 2021 Oct 11;11(10):e051433. doi: 10.1136/bmjopen-2021-051433. BMJ Open. 2021. PMID: 34635525 Free PMC article.
Despite that, data on PCD ENT manifestations are scarce and based on small single-centre studies. To date, we know little about the spectrum and severity of PCD ENT disease, its association with lung disease, its course over life and its determinants of progn …
Despite that, data on PCD ENT manifestations are scarce and based on small single-centre studies. To date, we know little about the spectrum …
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes.
Garcia-Aymerich J, Gómez FP, Benet M, Farrero E, Basagaña X, Gayete À, Paré C, Freixa X, Ferrer J, Ferrer A, Roca J, Gáldiz JB, Sauleda J, Monsó E, Gea J, Barberà JA, Agustí À, Antó JM; PAC-COPD Study Group. Garcia-Aymerich J, et al. Thorax. 2011 May;66(5):430-7. doi: 10.1136/thx.2010.154484. Epub 2010 Dec 21. Thorax. 2011. PMID: 21177668 Free article.
METHODS: To identify and validate COPD subtypes, 342 subjects hospitalised for the first time because of a COPD exacerbation were recruited. Three months after discharge, when clinically stable, symptoms and quality of life, lung function, exercise capacity, …
METHODS: To identify and validate COPD subtypes, 342 subjects hospitalised for the first time because of a COPD exacerbation were rec …
Moderately preterm children have more respiratory problems during their first 5 years of life than children born full term.
Vrijlandt EJ, Kerstjens JM, Duiverman EJ, Bos AF, Reijneveld SA. Vrijlandt EJ, et al. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1234-40. doi: 10.1164/rccm.201211-2070OC. Am J Respir Crit Care Med. 2013. PMID: 23525931 Clinical Trial.
METHODS: Prospective cohort study. OUTCOME VARIABLES: number of rehospitalizations caused by respiratory problems, prevalence of respiratory symptoms determined by ISAAC Questionnaires, and factors associated with respiratory symptoms …
METHODS: Prospective cohort study. OUTCOME VARIABLES: number of rehospitalizations caused by respiratory problems, prevalence …
Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhood.
Devulapalli CS. Devulapalli CS. Clin Respir J. 2008 Oct;2(4):247-8. doi: 10.1111/j.1752-699X.2008.00064.x. Clin Respir J. 2008. PMID: 20298343
INTRODUCTION: The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear. AIMS: This study was conducted (i) to determine how often ICS were used for treatment of obstructive airways disease (OAD) in early childhood; (ii) to …
INTRODUCTION: The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear. AIMS: This study was …
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