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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
1936 6
1937 10
1938 7
1939 4
1941 1
1942 1
1943 2
1945 2
1946 13
1947 10
1948 10
1949 21
1950 14
1951 27
1952 25
1953 22
1954 32
1955 24
1956 27
1957 24
1958 47
1959 28
1960 29
1961 33
1962 32
1963 72
1964 110
1965 80
1966 65
1967 92
1968 90
1969 124
1970 129
1971 155
1972 170
1973 159
1974 158
1975 221
1976 212
1977 173
1978 181
1979 160
1980 133
1981 171
1982 159
1983 182
1984 158
1985 156
1986 186
1987 194
1988 167
1989 207
1990 223
1991 221
1992 220
1993 234
1994 230
1995 225
1996 213
1997 188
1998 165
1999 184
2000 175
2001 164
2002 150
2003 168
2004 160
2005 174
2006 196
2007 245
2008 260
2009 284
2010 254
2011 267
2012 297
2013 298
2014 313
2015 279
2016 270
2017 245
2018 264
2019 252
2020 271
2021 273
2022 258
2023 264
2024 218
2025 248
2026 1

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12,142 results

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Page 1
Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review.
Boer C, Meesters MI, Veerhoek D, Vonk ABA. Boer C, et al. Br J Anaesth. 2018 May;120(5):914-927. doi: 10.1016/j.bja.2018.01.023. Epub 2018 Feb 26. Br J Anaesth. 2018. PMID: 29661409 Free article. Review.
Neutralisation of systemic anticoagulation with heparin in cardiac surgery with cardiopulmonary bypass requires protamine administration. If adequately dosed, protamine neutralises heparin and reduces the risk of postoperative bleeding. ...The available evidence sug …
Neutralisation of systemic anticoagulation with heparin in cardiac surgery with cardiopulmonary bypass requires protamine administrat …
Protamine--antagonist to heparin.
Jaques LB. Jaques LB. Can Med Assoc J. 1973 May 19;108(10):1291-7. Can Med Assoc J. 1973. PMID: 4122234 Free PMC article. Review.
Simple rules for the amount of protamine required for an individual patient based on clinical judgement will be satisfactory in most cases. When hemostasis is not achieved, it must be appreciated that heparin and protamine are only part of a complex deteriorating si …
Simple rules for the amount of protamine required for an individual patient based on clinical judgement will be satisfactory in most …
Protamine alterations in human spermatozoa.
Jodar M, Oliva R. Jodar M, et al. Adv Exp Med Biol. 2014;791:83-102. doi: 10.1007/978-1-4614-7783-9_6. Adv Exp Med Biol. 2014. PMID: 23955674 Review.
The fact that protamine haploinsufficiency in mice resulted in abnormal chromatin packaging and male infertility suggested that the protamines could also be important candidates in explaining some of the idiopathic male infertility cases in humans. The first clinica …
The fact that protamine haploinsufficiency in mice resulted in abnormal chromatin packaging and male infertility suggested that the …
Protamine: a review of its toxicity.
Horrow JC. Horrow JC. Anesth Analg. 1985 Mar;64(3):348-61. Anesth Analg. 1985. PMID: 3883848 Review.
Left atrial or aortic administration of protamine may not confer protection from its hemodynamic or idiosyncratic sequelae (see below). Little evidence exists to conclude that protamine directly depresses contractility of the human heart....
Left atrial or aortic administration of protamine may not confer protection from its hemodynamic or idiosyncratic sequelae (see below …
Protamine 2 precursors and processing.
de Mateo S, Ramos L, de Boer P, Meistrich M, Oliva R. de Mateo S, et al. Protein Pept Lett. 2011 Aug;18(8):778-85. doi: 10.2174/092986611795713998. Protein Pept Lett. 2011. PMID: 21443491 Review.
Protamine 2 (P2) is synthesised as a precursor protein (pre-P2) which by proteolysis is processed to generate the mature components of the protamine 2 family of proteins (HP2, HP3 and HP4). In infertile patients, abnormal processing of the protamine 2 precurs …
Protamine 2 (P2) is synthesised as a precursor protein (pre-P2) which by proteolysis is processed to generate the mature components o …
Protamine folds DNA into flowers and loop stacks.
McMillan RB, Bediako H, Devenica LM, Velasquez A, Hardy IP, Ma YE, Roscoe DM, Carter AR. McMillan RB, et al. Biophys J. 2023 Nov 7;122(21):4288-4302. doi: 10.1016/j.bpj.2023.10.003. Epub 2023 Oct 6. Biophys J. 2023. PMID: 37803830 Free PMC article.
To produce this dense packing, DNA is dramatically reorganized in minutes by protamine proteins. Protamines are positively charged proteins that coat negatively charged DNA and fold it into a series of toroids. ...These results highlight how protamine uses a …
To produce this dense packing, DNA is dramatically reorganized in minutes by protamine proteins. Protamines are positively cha …
Protamine-Mediated Tangles Produce Extreme Deoxyribonucleic Acid Compaction.
Ahlawat V, Dhiman A, Mudiyanselage HE, Zhou HX. Ahlawat V, et al. J Am Chem Soc. 2024 Nov 6;146(44):30668-30677. doi: 10.1021/jacs.4c12468. Epub 2024 Oct 29. J Am Chem Soc. 2024. PMID: 39469863 Free PMC article.
In sperm cells, protamine replaces histones to compact DNA 10-20 times more than in somatic cells. To characterize the extreme compaction, we employed confocal microscopy and optical tweezers to determine the conformations and stability of protamine-bound lambda-DNA …
In sperm cells, protamine replaces histones to compact DNA 10-20 times more than in somatic cells. To characterize the extreme compac …
Protamine-The Journey from DNA to Heparin Neutralization to Gene therapy.
Thachil J. Thachil J. Semin Thromb Hemost. 2022 Mar;48(2):240-243. doi: 10.1055/s-0041-1736574. Epub 2021 Nov 2. Semin Thromb Hemost. 2022. PMID: 34729729
Protamine is now well recognized as a key heparin neutralizing agent. However, protamine was discovered over a century ago, during experiments performed to uncover the secrets behind heritability. Although protamine was discovered as a highly charged protein, …
Protamine is now well recognized as a key heparin neutralizing agent. However, protamine was discovered over a century ago, du …
Protamine-Controlled Reversible DNA Packaging: A Molecular Glue.
Mukherjee A, de Izarra A, Degrouard J, Olive E, Maiti PK, Jang YH, Lansac Y. Mukherjee A, et al. ACS Nano. 2021 Aug 24;15(8):13094-13104. doi: 10.1021/acsnano.1c02337. Epub 2021 Jul 30. ACS Nano. 2021. PMID: 34328301
The reversible microscopic mechanisms induced by protamination modulation should provide valuable information to improve a mechanistic understanding of early and intermediate stages of spermatogenesis where an interplay between condensation and liquid-liquid phase separati …
The reversible microscopic mechanisms induced by protamination modulation should provide valuable information to improve a mechanisti …
Protamine-induced immune thrombocytopenia.
Singla A, Sullivan MJ, Lee G, Bartholomew J, Kapadia S, Aster RH, Curtis BR. Singla A, et al. Transfusion. 2013 Oct;53(10):2158-63. doi: 10.1111/trf.12112. Epub 2013 Feb 5. Transfusion. 2013. PMID: 23384227 Free PMC article.
We encountered a patient who experienced profound thrombocytopenia and bleeding shortly after administration of protamine and performed studies to characterize the responsible mechanism. STUDY DESIGN AND METHODS: Patient serum was studied for antibodies that recognize p …
We encountered a patient who experienced profound thrombocytopenia and bleeding shortly after administration of protamine and perform …
12,142 results
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