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Page 1
Oxidative Stress and the KEAP1/NRF2 Axis in Saphenous Vein: Implications for Graft Patency.
Layton GR, Marston E, Musa HL, Ladak S, Copperwheat A, Oluwanifemi A, Antoun I, Zakkar M. Layton GR, et al. Cells. 2026 Mar 20;15(6):563. doi: 10.3390/cells15060563. Cells. 2026. PMID: 41892352 Free PMC article. Review.
RESULTS: Only one study has directly evaluated NRF2 pathway activation directly in human saphenous vein tissue, and it demonstrated that Protandim (a herbal dietary supplement) treatment increased antioxidant enzyme activity and reduced oxidative stress markers, including …
RESULTS: Only one study has directly evaluated NRF2 pathway activation directly in human saphenous vein tissue, and it demonstrated that …
Limited impacts of dietary Protandim Nrf2 Synergizer on antioxidant and inflammatory status of mature, sedentary horses.
Semanchik PL, Wesolowski LT, Artman JL, Seward RL, Beer C, Barnes ED, White-Springer SH. Semanchik PL, et al. J Anim Sci. 2026 Jan 8;104:skaf433. doi: 10.1093/jas/skaf433. J Anim Sci. 2026. PMID: 41397914 Free PMC article.
Dietary supplementation of up to 4,050 mg/d Protandim Nrf2 Synergizer did not impact antioxidant status or plasma cytokines in mature, sedentary horses. ...No other differences were observed at the Protandim concentrations tested but further research evaluating an i …
Dietary supplementation of up to 4,050 mg/d Protandim Nrf2 Synergizer did not impact antioxidant status or plasma cytokines in mature …
Healthy Aging Interventions Reduce Repetitive Element Transcripts.
Wahl D, Cavalier AN, Smith M, Seals DR, LaRocca TJ. Wahl D, et al. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):805-810. doi: 10.1093/gerona/glaa302. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33257951 Free PMC article.
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-alpha-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and …
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie r …
NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.
Priestley JRC, Fink KE, McCord JM, Lombard JH. Priestley JRC, et al. Microcirculation. 2019 Oct;26(7):e12575. doi: 10.1111/micc.12575. Epub 2019 Jun 19. Microcirculation. 2019. PMID: 31132190 Free PMC article.
The restored dilation to ACh in MCA of Protandim-treated rats was prevented by inhibiting nitric oxide synthase (NOS) with L-NAME [100 muM] and was absent in MCA from Nrf2((-/-)) knockout rats fed HS diet. Basilar arteries from HS-fed rats treated with Protandim exh …
The restored dilation to ACh in MCA of Protandim-treated rats was prevented by inhibiting nitric oxide synthase (NOS) with L-NAME [10 …
Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies.
Song Y, Sun H, Xiao J, Wang F, Ding Y, Zhao J, Bai J, Cheng L, Gao K, Liu M, Guo Q, Zhang Y, Gao W, Jia Y, Wen A. Song Y, et al. J Pharm Biomed Anal. 2019 Jun 5;170:54-62. doi: 10.1016/j.jpba.2019.03.024. Epub 2019 Mar 14. J Pharm Biomed Anal. 2019. PMID: 30904740
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate (EGCG), silibinin (SIL), and curcumin (CUR) were simultaneously analyzed through a liquid chromatography-tandem mass spectrometric (LC-MS/MS …
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate …
Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise.
Bruns DR, Ehrlicher SE, Khademi S, Biela LM, Peelor FF 3rd, Miller BF, Hamilton KL. Bruns DR, et al. J Appl Physiol (1985). 2018 Aug 1;125(2):661-671. doi: 10.1152/japplphysiol.00277.2018. Epub 2018 Jun 1. J Appl Physiol (1985). 2018. PMID: 29856263 Free PMC article.
Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulates endogenous antioxidants, permits mitochondrial biogenesis. We confirm that vitamin C blunts aerobic exercise adaptions, whereas Protand …
Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulate …
Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.
Konopka AR, Laurin JL, Musci RV, Wolff CA, Reid JJ, Biela LM, Zhang Q, Peelor FF 3rd, Melby CL, Hamilton KL, Miller BF. Konopka AR, et al. Geroscience. 2017 Apr;39(2):175-186. doi: 10.1007/s11357-017-9968-8. Epub 2017 Mar 10. Geroscience. 2017. PMID: 28283797 Free PMC article. Clinical Trial.
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim versus CON. Similarly, DNA synthesis was non-significantly lower after Protandim compared to CON. ...Overall, these data suggest tha …
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim …
Protandim Protects Oligodendrocytes against an Oxidative Insult.
Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J. Lim JL, et al. Antioxidants (Basel). 2016 Sep 7;5(3):30. doi: 10.3390/antiox5030030. Antioxidants (Basel). 2016. PMID: 27618111 Free PMC article.
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which inhibited OPC differentiation. Protandim significantly promoted OPC differentiation under influence of ROS, but not TNF. ...
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which …
The Effect of Protandim Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.
Ueberschlag SL, Seay JR, Roberts AH, DeSpirito PC, Stith JM, Folz RJ, Carter KA, Weiss EP, Zavorsky GS. Ueberschlag SL, et al. PLoS One. 2016 Aug 11;11(8):e0160559. doi: 10.1371/journal.pone.0160559. eCollection 2016. PLoS One. 2016. PMID: 27513339 Free PMC article. Clinical Trial.
Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) after three months of Protandim supplementation compared to place …
Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardl …
30 results