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Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise.
Bruns DR, Ehrlicher SE, Khademi S, Biela LM, Peelor FF 3rd, Miller BF, Hamilton KL. Bruns DR, et al. J Appl Physiol (1985). 2018 Aug 1;125(2):661-671. doi: 10.1152/japplphysiol.00277.2018. Epub 2018 Jun 1. J Appl Physiol (1985). 2018. PMID: 29856263 Free PMC article.
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulates endogenous antio …
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we sh …
Healthy Aging Interventions Reduce Repetitive Element Transcripts.
Wahl D, Cavalier AN, Smith M, Seals DR, LaRocca TJ. Wahl D, et al. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):805-810. doi: 10.1093/gerona/glaa302. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33257951 Free PMC article.
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-alpha-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and …
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie r …
The Effect of Protandim Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.
Ueberschlag SL, Seay JR, Roberts AH, DeSpirito PC, Stith JM, Folz RJ, Carter KA, Weiss EP, Zavorsky GS. Ueberschlag SL, et al. PLoS One. 2016 Aug 11;11(8):e0160559. doi: 10.1371/journal.pone.0160559. eCollection 2016. PLoS One. 2016. PMID: 27513339 Free PMC article. Clinical Trial.
Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) after three months of Protandim supplementation compared to placebo …
Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardle …
The role of Nrf2 in the attenuation of cardiovascular disease.
Reuland DJ, McCord JM, Hamilton KL. Reuland DJ, et al. Exerc Sport Sci Rev. 2013 Jul;41(3):162-8. doi: 10.1097/JES.0b013e3182948a1e. Exerc Sport Sci Rev. 2013. PMID: 23558695 Review.
Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review hi …
Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals …
Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge.
Donovan EL, McCord JM, Reuland DJ, Miller BF, Hamilton KL. Donovan EL, et al. Oxid Med Cell Longev. 2012;2012:132931. doi: 10.1155/2012/132931. Epub 2012 May 22. Oxid Med Cell Longev. 2012. PMID: 22685617 Free PMC article.

Treatment of HCAEC with H(2)O(2) induced apoptosis in 34% of cells while pretreatment with Protandim resulted in only 6% apoptotic cells (P < 0.01). Nrf2 silencing significantly decreased the Protandim-induced increase in HO-1 protein (P < 0.01). ...These resu

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Treatment of HCAEC with H(2)O(2) induced apoptosis in 34% of cells while pretreatment with Protandim resulted in only 6% apoptotic ce …
Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.
Konopka AR, Laurin JL, Musci RV, Wolff CA, Reid JJ, Biela LM, Zhang Q, Peelor FF 3rd, Melby CL, Hamilton KL, Miller BF. Konopka AR, et al. Geroscience. 2017 Apr;39(2):175-186. doi: 10.1007/s11357-017-9968-8. Epub 2017 Mar 10. Geroscience. 2017. PMID: 28283797 Free PMC article. Clinical Trial.
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim versus CON. Similarly, DNA synthesis was non-significantly lower after Protandim compared to CON. ...Overall, these data suggest tha …
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim …
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.
Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL. Reuland DJ, et al. Free Radic Biol Med. 2013 Mar;56:102-11. doi: 10.1016/j.freeradbiomed.2012.11.016. Epub 2012 Nov 30. Free Radic Biol Med. 2013. PMID: 23201694
The purpose of these experiments was to determine if treatment of cardiomyocytes with this phytochemical composition, marketed as Protandim, activates Nrf2, induces phase II detoxification enzymes, and protects cardiomyocytes from oxidant-induced apoptosis in a Nrf2-depend …
The purpose of these experiments was to determine if treatment of cardiomyocytes with this phytochemical composition, marketed as Protand …