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360 results

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Page 1
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy.
Guo Y, Wan R, Duan J, Yuan L, Wang Z, Zhong J, Zhang X, Ma Z, Bai H, Wang J. Guo Y, et al. Signal Transduct Target Ther. 2025 Mar 17;10(1):99. doi: 10.1038/s41392-025-02190-2. Signal Transduct Target Ther. 2025. PMID: 40090947 Free PMC article.
Here, we uncovered the potential of plasma S100 calcium-binding protein A1 (S100A1) for determining ICB efficacy via liquid biopsy of patients with lung cancer. Multiomics and functional studies have suggested that tumor-intrinsic S100A1 expression correlated with a …
Here, we uncovered the potential of plasma S100 calcium-binding protein A1 (S100A1) for determining ICB efficacy via liquid biopsy of …
Targeting S100A1 in heart failure.
Ritterhoff J, Most P. Ritterhoff J, et al. Gene Ther. 2012 Jun;19(6):613-21. doi: 10.1038/gt.2012.8. Epub 2012 Feb 16. Gene Ther. 2012. PMID: 22336719 Review.
S100A1 was shown to regulate sarcoplasmic reticulum, sarcomere and mitochondrial function by modulating target protein activity. ...Proof-of-concept studies in small and large animal models as wells as in human failing CM could demonstrate feasibility and efficacy of S1 …
S100A1 was shown to regulate sarcoplasmic reticulum, sarcomere and mitochondrial function by modulating target protein activity. ...P …
S100A1: a major player in cardiovascular performance.
Duarte-Costa S, Castro-Ferreira R, Neves JS, Leite-Moreira AF. Duarte-Costa S, et al. Physiol Res. 2014;63(6):669-81. doi: 10.33549/physiolres.932712. Epub 2014 Aug 26. Physiol Res. 2014. PMID: 25157660 Free article. Review.
In fact, S100A1 seems to normalize cardiac function after myocardial infarction. Also, S100A1 is essential in the acute response to adrenergic stimulation. ...Finally, we discuss S100A1 gene therapy and its progression so far....
In fact, S100A1 seems to normalize cardiac function after myocardial infarction. Also, S100A1 is essential in the acute respon …
S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models.
Kehr D, Ritterhoff J, Glaser M, Jarosch L, Salazar RE, Spaich K, Varadi K, Birkenstock J, Egger M, Gao E, Koch WJ, Sauter M, Freichel M, Katus HA, Frey N, Jungmann A, Busch C, Mather PJ, Ruhparwar A, Busch M, Völkers M, Wade RC, Most P. Kehr D, et al. Circulation. 2025 Feb 25;151(8):548-565. doi: 10.1161/CIRCULATIONAHA.123.066961. Epub 2024 Nov 21. Circulation. 2025. PMID: 39569500 Free PMC article.
BACKGROUND: The EF-hand Ca(2+) sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. ...We hypothesized that a synthetic peptide consisting of residues 75 through 94 of S100A1 and an N-terminal solubilization tag (S1 …
BACKGROUND: The EF-hand Ca(2+) sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance …
Cardiomyocytes, endothelial cells and cardiac fibroblasts: S100A1's triple action in cardiovascular pathophysiology.
Rohde D, Busch M, Volkert A, Ritterhoff J, Katus HA, Peppel K, Most P. Rohde D, et al. Future Cardiol. 2015 May;11(3):309-21. doi: 10.2217/fca.15.18. Future Cardiol. 2015. PMID: 26021637 Free PMC article. Review.
Lack of S100A1 release in ischemic myocardium compromises cardiac fibroblast function, entailing impaired damage healing. This review focuses on molecular pathways and signaling cascades regulated by S100A1 in cardiomyocytes, endothelial cells and cardiac fibroblast …
Lack of S100A1 release in ischemic myocardium compromises cardiac fibroblast function, entailing impaired damage healing. This review …
S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function.
Völkers M, Rohde D, Goodman C, Most P. Völkers M, et al. J Biomed Biotechnol. 2010;2010:178614. doi: 10.1155/2010/178614. Epub 2010 Mar 28. J Biomed Biotechnol. 2010. PMID: 20368797 Free PMC article. Review.
Early studies revealed distinct expression patterns of S100A1 in healthy and diseased cardiac tissue from animal models and humans. Further elaborate investigations uncovered S100A1 protein as a basic requirement for striated muscle Ca(2+) handling integrity. …
Early studies revealed distinct expression patterns of S100A1 in healthy and diseased cardiac tissue from animal models and humans. F …
S100A1 and S100B: Calcium Sensors at the Cross-Roads of Multiple Chondrogenic Pathways.
Diaz-Romero J, Nesic D. Diaz-Romero J, et al. J Cell Physiol. 2017 Aug;232(8):1979-1987. doi: 10.1002/jcp.25720. Epub 2017 Mar 24. J Cell Physiol. 2017. PMID: 27925190 Review.
This review summarizes reported intracellular S100A1 and S100B regulatory functions described in other cell types that could be also involved in the regulation of chondrogenic processes in cartilage. Potential roles of S100A1 and S100B in the TGF-beta-SMAD, the cAMP …
This review summarizes reported intracellular S100A1 and S100B regulatory functions described in other cell types that could be also …
Structural insights into the regulation of RyR1 by S100A1.
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR. Weninger G, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2400497121. doi: 10.1073/pnas.2400497121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38917010 Free PMC article.
Here, we report cryoelectron microscopy structures of S100A1 bound to RyR1, the skeletal muscle isoform, in absence and presence of Ca(2+). Ca(2+)-free apo-S100A1 binds beneath the bridging solenoid (BSol) and forms contacts with the junctional solenoid and the shel …
Here, we report cryoelectron microscopy structures of S100A1 bound to RyR1, the skeletal muscle isoform, in absence and presence of C …
The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP.
Melville Z, Hernández-Ochoa EO, Pratt SJP, Liu Y, Pierce AD, Wilder PT, Adipietro KA, Breysse DH, Varney KM, Schneider MF, Weber DJ. Melville Z, et al. Biochemistry. 2017 May 2;56(17):2328-2337. doi: 10.1021/acs.biochem.7b00117. Epub 2017 Apr 18. Biochemistry. 2017. PMID: 28409622 Free PMC article.
The interaction was specific for S100A1 because other calcium-binding proteins (i.e., S100B and calmodulin) had no effect. Likewise, a role for S100A1 in PKA-dependent signaling was established because the PKA-dependent subcellular redistribution of HDAC4 was abolis …
The interaction was specific for S100A1 because other calcium-binding proteins (i.e., S100B and calmodulin) had no effect. Likewise, …
S100A1: a multifaceted therapeutic target in cardiovascular disease.
Rohde D, Ritterhoff J, Voelkers M, Katus HA, Parker TG, Most P. Rohde D, et al. J Cardiovasc Transl Res. 2010 Oct;3(5):525-37. doi: 10.1007/s12265-010-9211-9. Epub 2010 Jul 20. J Cardiovasc Transl Res. 2010. PMID: 20645037 Free PMC article. Review.
Emphasizing the pathophysiological relevance of S100A1, myocardial infarction in S100A1 knockout mice resulted in accelerated transition towards heart failure and excessive mortality in comparison with wild-type controls. Mice lacking S100A1 furthermore displ …
Emphasizing the pathophysiological relevance of S100A1, myocardial infarction in S100A1 knockout mice resulted in accelerated …
360 results