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Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma.
Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J, Qian X, He F; Chinese Human Proteome Project (CNHPP) Consortium. Jiang Y, et al. Nature. 2019 Mar;567(7747):257-261. doi: 10.1038/s41586-019-0987-8. Epub 2019 Feb 27. Nature. 2019. PMID: 30814741
Our quantitative proteomic data highlight heterogeneity in early-stage hepatocellular carcinoma: we used this to stratify the cohort into the subtypes S-I, S-II and S-III, each of which has a different clinical outcome. ...The proteomic s …
Our quantitative proteomic data highlight heterogeneity in early-stage hepatocellular carcinoma: we used …
Proteomics of hepatocellular carcinoma in Chinese patients.
Luk JM, Liu AM. Luk JM, et al. OMICS. 2011 May;15(5):261-6. doi: 10.1089/omi.2010.0099. Epub 2011 Feb 24. OMICS. 2011. PMID: 21348761 Free article. Review.
Hepatocellular carcinoma (HCC) is a malignant tumor of liver that causes approximately half a million deaths each year, of which over half of the cases are diagnosed in China. ...Such new horizons of integrated profiling informatics have allowed us to search …
Hepatocellular carcinoma (HCC) is a malignant tumor of liver that causes approximately half a million deaths each year, of whi …
RNF149 Promotes HCC Progression through Its E3 Ubiquitin Ligase Activity.
Guo Z, Jiang P, Dong Q, Zhang Y, Xu K, Zhai Y, He F, Tian C, Sun A. Guo Z, et al. Cancers (Basel). 2023 Oct 29;15(21):5203. doi: 10.3390/cancers15215203. Cancers (Basel). 2023. PMID: 37958377 Free PMC article.
Hepatocellular carcinoma (HCC) accounts for over 80% of cases among liver cancer, with high incidence and poor prognosis. Thus, it is of valuable clinical significance for discovery of potential biomarkers and drug targets for HCC. In this study, based on the …
Hepatocellular carcinoma (HCC) accounts for over 80% of cases among liver cancer, with high incidence and poor prognosis. Thus …
Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles.
Yamaguchi H, Kuroda K, Sugitani M, Takayama T, Hasegawa K, Esumi M. Yamaguchi H, et al. Int J Oncol. 2017 May;50(5):1749-1759. doi: 10.3892/ijo.2017.3917. Epub 2017 Mar 20. Int J Oncol. 2017. PMID: 28339069
The mechanism of early recurrence of hepato-cellular carcinoma (HCC) is not well understood. To examine whether early intrahepatic metastasis of HCC can be determined by the reliable molecular characteristics of the primary HCC, we focused on early-stage tumo …
The mechanism of early recurrence of hepato-cellular carcinoma (HCC) is not well understood. To examine whether early intrahepatic me …
Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.
Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Everaert C, Jovanovic M, Mertins P, Carr SA, Chayama K, Dali-Youcef N, Ricci R, Bardeesy NM, Fujiwara N, Gevaert O, Zeisel MB, Hoshida Y, Pochet N, Baumert TF. Lupberger J, et al. Gastroenterology. 2019 Aug;157(2):537-551.e9. doi: 10.1053/j.gastro.2019.04.003. Epub 2019 Apr 9. Gastroenterology. 2019. PMID: 30978357 Free PMC article.
Using differential expression, gene set enrichment analyses, and protein interaction mapping, we identified pathways that changed in response to HCV infection. We validated our findings in studies of liver tissues from 216 patients with HCV infection and early-st …
Using differential expression, gene set enrichment analyses, and protein interaction mapping, we identified pathways that changed in …