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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1915 1
1916 1
1917 2
1935 3
1936 2
1937 3
1938 2
1939 2
1940 8
1941 7
1942 8
1944 1
1945 20
1946 53
1947 72
1948 74
1949 103
1950 130
1951 136
1952 173
1953 153
1954 155
1955 134
1956 105
1957 98
1958 83
1959 86
1960 74
1961 101
1962 105
1963 191
1964 304
1965 195
1966 168
1967 266
1968 315
1969 293
1970 309
1971 312
1972 346
1973 381
1974 373
1975 391
1976 293
1977 283
1978 280
1979 322
1980 280
1981 322
1982 306
1983 338
1984 374
1985 441
1986 413
1987 384
1988 368
1989 461
1990 447
1991 458
1992 528
1993 544
1994 617
1995 586
1996 621
1997 688
1998 742
1999 837
2000 811
2001 798
2002 844
2003 885
2004 864
2005 931
2006 861
2007 951
2008 929
2009 954
2010 998
2011 1079
2012 1168
2013 1216
2014 1216
2015 1218
2016 1147
2017 1096
2018 1109
2019 1115
2020 1357
2021 1379
2022 1247
2023 1161
2024 391

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39,692 results

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Page 1
The prothrombin gene.
MacGillivray RT, Irwin DM. MacGillivray RT, et al. Haemostasis. 1986;16(3-4):227-38. doi: 10.1159/000215295. Haemostasis. 1986. PMID: 3530900 Review.
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues. Us …
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural stu …
The biology of prothrombin.
Degen SJ, Sun WY. Degen SJ, et al. Crit Rev Eukaryot Gene Expr. 1998;8(2):203-24. doi: 10.1615/critreveukargeneexpr.v8.i2.60. Crit Rev Eukaryot Gene Expr. 1998. PMID: 9714898 Review.
Prothrombin and thrombin are involved in diverse biological functions. ...Prothrombin deficiency in mice results in partial embryonic lethality. ...
Prothrombin and thrombin are involved in diverse biological functions. ...Prothrombin deficiency in mice results in partial em …
Human prothrombin activation.
Downing MR, Butkowski RJ, Clark MM, Mann KG. Downing MR, et al. J Biol Chem. 1975 Dec 10;250(23):8897-906. J Biol Chem. 1975. PMID: 1238394 Free article.
Studies of the activation of the human prothrombin with the use of sodium dodecyl sulfate electrophoretic analysis of activation products indicated that human prothrombin activation is similar to bovine prothrombin activation. ...Amino acid compositions of hu …
Studies of the activation of the human prothrombin with the use of sodium dodecyl sulfate electrophoretic analysis of activation prod …
Prothrombin structure: unanticipated features and opportunities.
Pozzi N, Di Cera E. Pozzi N, et al. Expert Rev Proteomics. 2014 Dec;11(6):653-5. doi: 10.1586/14789450.2014.971763. Epub 2014 Oct 18. Expert Rev Proteomics. 2014. PMID: 25327788 Free PMC article.
The structure of prothrombin has eluded investigators for decades but recent efforts have succeeded in revealing the architecture of this important clotting factor. ...A new, structure-based framework helps in defining a molecular mechanism of prothrombin activation …
The structure of prothrombin has eluded investigators for decades but recent efforts have succeeded in revealing the architecture of …
Autoactivation of thrombin precursors.
Pozzi N, Chen Z, Zapata F, Niu W, Barranco-Medina S, Pelc LA, Di Cera E. Pozzi N, et al. J Biol Chem. 2013 Apr 19;288(16):11601-10. doi: 10.1074/jbc.M113.451542. Epub 2013 Mar 6. J Biol Chem. 2013. PMID: 23467412 Free PMC article.
Central to this paradigm is that the zymogen does not convert spontaneously to the mature enzyme, which in turn does not feed back to activate its zymogen form. In the blood, the zymogens prothrombin and prethrombin-2 require the prothrombinase complex to be converted to t …
Central to this paradigm is that the zymogen does not convert spontaneously to the mature enzyme, which in turn does not feed back to activa …
Diagnosis of primary hepatocellular carcinoma.
Tong MJ. Tong MJ. Gastroenterology. 1986 Nov;91(5):1306-7. doi: 10.1016/s0016-5085(86)80033-6. Gastroenterology. 1986. PMID: 2428693 No abstract available.
Prothrombin cleaving antibody light chains.
Thiagarajan P, Paul S. Thiagarajan P, et al. Chem Immunol. 2000;77:115-29. doi: 10.1159/000058801. Chem Immunol. 2000. PMID: 11706702 Review. No abstract available.
Prothrombin activation.
Mann KG. Mann KG. Hum Pathol. 1974 Jul;5(4):377-9. doi: 10.1016/s0046-8177(74)80017-1. Hum Pathol. 1974. PMID: 4857813 No abstract available.
Snake venom prothrombin activators similar to blood coagulation factor Xa.
Joseph JS, Kini RM. Joseph JS, et al. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec;4(4):397-416. doi: 10.2174/1568006043335781. Curr Drug Targets Cardiovasc Haematol Disord. 2004. PMID: 15578960 Review.
Activation of prothrombin to mature thrombin in vivo occurs by the proteolytic action of the prothrombinase complex consisting of serine proteinase factor Xa, and cofactors that include factor Va, Ca(2+) ions and phospholipids. Several exogenous prothrombin activato …
Activation of prothrombin to mature thrombin in vivo occurs by the proteolytic action of the prothrombinase complex consisting of ser …
Miguel Llinás and the Structure of the Kringle Fold.
Patthy L. Patthy L. Protein J. 2021 Aug;40(4):450-453. doi: 10.1007/s10930-021-09981-w. Epub 2021 Mar 31. Protein J. 2021. PMID: 33791899 Free PMC article. No abstract available.
39,692 results
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