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Targeting bile-acid signalling for metabolic diseases.
Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Thomas C, et al. Among authors: pruzanski m. Nat Rev Drug Discov. 2008 Aug;7(8):678-93. doi: 10.1038/nrd2619. Nat Rev Drug Discov. 2008. PMID: 18670431 Review.
TGR5-mediated bile acid sensing controls glucose homeostasis.
Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. Thomas C, et al. Among authors: pruzanski m. Cell Metab. 2009 Sep;10(3):167-77. doi: 10.1016/j.cmet.2009.08.001. Cell Metab. 2009. PMID: 19723493 Free PMC article.
Probing the Binding Site of Bile Acids in TGR5.
Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R. Macchiarulo A, et al. Among authors: pruzanski m. ACS Med Chem Lett. 2013 Oct 15;4(12):1158-62. doi: 10.1021/ml400247k. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900622 Free PMC article.
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour BM, Sabatino G, Russo G, Castellani D, Willson TM, Pruzanski M, Pellicciari R, Morelli A. Fiorucci S, et al. Among authors: pruzanski m. J Pharmacol Exp Ther. 2005 May;313(2):604-12. doi: 10.1124/jpet.104.079665. Epub 2005 Jan 11. J Pharmacol Exp Ther. 2005. PMID: 15644430
Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis.
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R. Fiorucci S, et al. Among authors: pruzanski m. J Pharmacol Exp Ther. 2005 Oct;315(1):58-68. doi: 10.1124/jpet.105.085597. Epub 2005 Jun 24. J Pharmacol Exp Ther. 2005. PMID: 15980055
Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.
Pellicciari R, Gioiello A, Sabbatini P, Venturoni F, Nuti R, Colliva C, Rizzo G, Adorini L, Pruzanski M, Roda A, Macchiarulo A. Pellicciari R, et al. Among authors: pruzanski m. ACS Med Chem Lett. 2012 Feb 6;3(4):273-7. doi: 10.1021/ml200256d. eCollection 2012 Apr 12. ACS Med Chem Lett. 2012. PMID: 24900463 Free PMC article.
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. Fiorucci S, et al. Among authors: pruzanski m. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. doi: 10.1124/jpet.105.084905. Epub 2005 Apr 28. J Pharmacol Exp Ther. 2005. PMID: 15860571
24 results