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Page 1
The Therapeutic Potential of Psilocybin.
Lowe H, Toyang N, Steele B, Valentine H, Grant J, Ali A, Ngwa W, Gordon L. Lowe H, et al. Molecules. 2021 May 15;26(10):2948. doi: 10.3390/molecules26102948. Molecules. 2021. PMID: 34063505 Free PMC article. Review.
This prohibition on psychedelic drug research significantly delayed advances in medical knowledge on the therapeutic uses of agents such as psilocybin. A 2004 pilot study from the University of California, Los Angeles, exploring the potential of psilocybin treatment …
This prohibition on psychedelic drug research significantly delayed advances in medical knowledge on the therapeutic uses of agents such as …
Psilocybin-assisted therapy for depression: A systematic review and meta-analysis.
Haikazian S, Chen-Li DCJ, Johnson DE, Fancy F, Levinta A, Husain MI, Mansur RB, McIntyre RS, Rosenblat JD. Haikazian S, et al. Psychiatry Res. 2023 Nov;329:115531. doi: 10.1016/j.psychres.2023.115531. Epub 2023 Oct 11. Psychiatry Res. 2023. PMID: 37844352 Review.
The meta-analysis included 9 studies (pooled n = 596) and yielded a large effect size in favour of psilocybin (SMD = -0.78; p<0.001). Risk ratios for response and remission were large and significant in favour of psilocybin. A review of open-label trials showed r …
The meta-analysis included 9 studies (pooled n = 596) and yielded a large effect size in favour of psilocybin (SMD = -0.78; p<0.00 …
Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance.
Dinis-Oliveira RJ. Dinis-Oliveira RJ. Drug Metab Rev. 2017 Feb;49(1):84-91. doi: 10.1080/03602532.2016.1278228. Epub 2017 Jan 31. Drug Metab Rev. 2017. PMID: 28074670 Review.
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)(2A) subtype receptors. ...This review aims to discuss me …
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mu …
Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression.
Ling S, Ceban F, Lui LMW, Lee Y, Teopiz KM, Rodrigues NB, Lipsitz O, Gill H, Subramaniapillai M, Mansur RB, Lin K, Ho R, Rosenblat JD, Castle D, McIntyre RS. Ling S, et al. CNS Drugs. 2022 Jan;36(1):17-30. doi: 10.1007/s40263-021-00877-y. Epub 2021 Nov 17. CNS Drugs. 2022. PMID: 34791625 Review.
Preliminary studies with psilocybin have shown therapeutic promise across diverse populations including major depressive disorder. ...Along with the direct effects on neurochemical systems, psilocybin alters neural circuitry and key brain regions previously implicat …
Preliminary studies with psilocybin have shown therapeutic promise across diverse populations including major depressive disorder. .. …
The pharmacology of psilocybin.
Passie T, Seifert J, Schneider U, Emrich HM. Passie T, et al. Addict Biol. 2002 Oct;7(4):357-64. doi: 10.1080/1355621021000005937. Addict Biol. 2002. PMID: 14578010 Review.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. ...Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocybin were known until rece …
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed world …
Psilocybin for Trauma-Related Disorders.
Khan AJ, Bradley E, O'Donovan A, Woolley J. Khan AJ, et al. Curr Top Behav Neurosci. 2022;56:319-332. doi: 10.1007/7854_2022_366. Curr Top Behav Neurosci. 2022. PMID: 35711024 Review.
We provide an overview of trauma and PTSD and cite literature providing converging evidence of the therapeutic potential of psilocybin for PTSD. No study to date has investigated psilocybin or psilocybin-assisted psychotherapy (PAP) as treatments for PTSD. .. …
We provide an overview of trauma and PTSD and cite literature providing converging evidence of the therapeutic potential of psilocybin …
Psilocybin: from ancient magic to modern medicine.
Nichols DE. Nichols DE. J Antibiot (Tokyo). 2020 Oct;73(10):679-686. doi: 10.1038/s41429-020-0311-8. Epub 2020 May 12. J Antibiot (Tokyo). 2020. PMID: 32398764 Review.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is an indole-based secondary metabolite produced by numerous species of mushrooms. ...At present, assuming that the early clinical studies can be validated by larger studies, psilocybin is poised to make a signific …
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is an indole-based secondary metabolite produced by numerous species of mushrooms …
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.
Carhart-Harris RL, Bolstridge M, Rucker J, Day CM, Erritzoe D, Kaelen M, Bloomfield M, Rickard JA, Forbes B, Feilding A, Taylor D, Pilling S, Curran VH, Nutt DJ. Carhart-Harris RL, et al. Lancet Psychiatry. 2016 Jul;3(7):619-27. doi: 10.1016/S2215-0366(16)30065-7. Epub 2016 May 17. Lancet Psychiatry. 2016. PMID: 27210031 Free article. Clinical Trial.
The primary outcome measure for feasibility was patient-reported intensity of psilocybin's effects. Patients were monitored for adverse reactions during the dosing sessions and subsequent clinic and remote follow-up. ...This trial is registered with ISRCTN, number I …
The primary outcome measure for feasibility was patient-reported intensity of psilocybin's effects. Patients were monitored fo …
Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial.
Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, Finan PH, Griffiths RR. Davis AK, et al. JAMA Psychiatry. 2021 May 1;78(5):481-489. doi: 10.1001/jamapsychiatry.2020.3285. JAMA Psychiatry. 2021. PMID: 33146667 Free PMC article. Clinical Trial.
Recent evidence suggests that 1 or 2 administrations of psilocybin with psychological support produces antidepressant effects in patients with cancer and in those with treatment-resistant depression. ...CONCLUSIONS AND RELEVANCE: Findings suggest that psilocybin wit …
Recent evidence suggests that 1 or 2 administrations of psilocybin with psychological support produces antidepressant effects in pati …
Psilocybin in Treatment-Resistant Depression.
Madras BK. Madras BK. N Engl J Med. 2022 Nov 3;387(18):1708-1709. doi: 10.1056/NEJMe2210975. N Engl J Med. 2022. PMID: 36322849 No abstract available.
2,401 results