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Activation of the HIF pathway in cancer.
Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Among authors: pugh cw. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
Pugh CW, Ratcliffe PJ. Pugh CW, et al. Semin Cancer Biol. 2003 Feb;13(1):83-9. doi: 10.1016/s1044-579x(02)00103-7. Semin Cancer Biol. 2003. PMID: 12507560 Review.
Hypoxia and HIF pathway in cancer and the placenta.
Macklin PS, McAuliffe J, Pugh CW, Yamamoto A. Macklin PS, et al. Among authors: pugh cw. Placenta. 2017 Aug;56:8-13. doi: 10.1016/j.placenta.2017.03.010. Epub 2017 Mar 16. Placenta. 2017. PMID: 28330647 Review.
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ. Bishop T, et al. Among authors: pugh cw. J Physiol. 2013 Jul 15;591(14):3565-77. doi: 10.1113/jphysiol.2012.247254. Epub 2013 May 20. J Physiol. 2013. PMID: 23690557 Free PMC article.
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR. Schödel J, et al. Among authors: pugh cw. Blood. 2011 Jun 9;117(23):e207-17. doi: 10.1182/blood-2010-10-314427. Epub 2011 Mar 29. Blood. 2011. PMID: 21447827 Free PMC article.
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
Jones DT, Pugh CW, Wigfield S, Stevens MF, Harris AL. Jones DT, et al. Among authors: pugh cw. Clin Cancer Res. 2006 Sep 15;12(18):5384-94. doi: 10.1158/1078-0432.CCR-05-2380. Clin Cancer Res. 2006. PMID: 17000671
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, Robbins PA. Smith TG, et al. Among authors: pugh cw. PLoS Med. 2006 Jul;3(7):e290. doi: 10.1371/journal.pmed.0030290. PLoS Med. 2006. PMID: 16768548 Free PMC article.
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Raval RR, et al. Among authors: pugh cw. Mol Cell Biol. 2005 Jul;25(13):5675-86. doi: 10.1128/MCB.25.13.5675-5686.2005. Mol Cell Biol. 2005. PMID: 15964822 Free PMC article.
Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.
Milkiewicz M, Pugh CW, Egginton S. Milkiewicz M, et al. Among authors: pugh cw. J Physiol. 2004 Oct 1;560(Pt 1):21-6. doi: 10.1113/jphysiol.2004.069757. Epub 2004 Aug 19. J Physiol. 2004. PMID: 15319416 Free PMC article.
Oxygen sensing in cancer.
Pugh CW. Pugh CW. Ann Med. 2003;35(6):380-90. doi: 10.1080/07853890310017062. Ann Med. 2003. PMID: 14572161 Review.
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