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The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake.
Shih YH, Pugsley TA. Shih YH, et al. Among authors: pugsley ta. Life Sci. 1985 Jun 3;36(22):2145-52. doi: 10.1016/0024-3205(85)90311-x. Life Sci. 1985. PMID: 2987637
Binding of leukotrienes C4 and D4 to membranes from guinea pig lung: regulation by ions and guanine nucleotides.
Bruns RF, Thomsen WJ, Pugsley TA. Bruns RF, et al. Among authors: pugsley ta. Life Sci. 1983 Aug 15;33(7):645-53. doi: 10.1016/0024-3205(83)90253-9. Life Sci. 1983. PMID: 6308377
Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells.
Akunne HC, Towers P, Ellis GJ, Dijkstra D, Wikström H, Heffner TG, Wise LD, Pugsley TA. Akunne HC, et al. Among authors: pugsley ta. Life Sci. 1995;57(15):1401-10. doi: 10.1016/0024-3205(95)02102-o. Life Sci. 1995. PMID: 7674830
Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.
Lippmann W, Pugsley T, Merker J. Lippmann W, et al. Among authors: pugsley t. Life Sci. 1975 Jan 15;16(2):213-24. doi: 10.1016/0024-3205(75)90019-3. Life Sci. 1975. PMID: 162971 No abstract available.
Aminopyrimidines with high affinity for both serotonin and dopamine receptors.
Wustrow D, Belliotti T, Glase S, Kesten SR, Johnson D, Colbry N, Rubin R, Blackburn A, Akunne H, Corbin A, Davis MD, Georgic L, Whetzel S, Zoski K, Heffner T, Pugsley T, Wise L. Wustrow D, et al. Among authors: pugsley t. J Med Chem. 1998 Feb 26;41(5):760-71. doi: 10.1021/jm9707378. J Med Chem. 1998. PMID: 9513604
The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists.
Pugsley TA, Shih YH, Whetzel SZ, Zoski K, Van Leeuwen D, Akunne H, Mackenzie R, Heffner TG, Wustrow D, Wise LD. Pugsley TA, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. doi: 10.1016/s0278-5846(01)00252-4. Prog Neuropsychopharmacol Biol Psychiatry. 2002. PMID: 11817497
Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.
Dijkstra D, Rodenhuis N, Vermeulen ES, Pugsley TA, Wise LD, Wikström HV. Dijkstra D, et al. Among authors: pugsley ta. J Med Chem. 2002 Jul 4;45(14):3022-31. doi: 10.1021/jm001015a. J Med Chem. 2002. PMID: 12086487
Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD. Böhme TM, et al. Among authors: pugsley t. J Med Chem. 2002 Jul 4;45(14):3094-102. doi: 10.1021/jm011116o. J Med Chem. 2002. PMID: 12086495
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).
van Vliet LA, Rodenhuis N, Dijkstra D, Wikström H, Pugsley TA, Serpa KA, Meltzer LT, Heffner TG, Wise LD, Lajiness ME, Huff RM, Svensson K, Sundell S, Lundmark M. van Vliet LA, et al. Among authors: pugsley ta. J Med Chem. 2000 Jul 27;43(15):2871-82. doi: 10.1021/jm0000113. J Med Chem. 2000. PMID: 10956195
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.
Belliotti TR, Wustrow DJ, Brink WA, Zoski KT, Shih YH, Whetzel SZ, Georgic LM, Corbin AE, Akunne HC, Heffner TG, Pugsley TA, Wise LD. Belliotti TR, et al. Among authors: pugsley ta. J Med Chem. 1999 Dec 16;42(25):5181-7. doi: 10.1021/jm990277d. J Med Chem. 1999. PMID: 10602703
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