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Unveiling the role of network and systems biology in drug discovery.
Pujol A, Mosca R, Farrés J, Aloy P. Pujol A, et al. Trends Pharmacol Sci. 2010 Mar;31(3):115-23. doi: 10.1016/j.tips.2009.11.006. Epub 2010 Feb 1. Trends Pharmacol Sci. 2010. PMID: 20117850 Review.
Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the key molecular details. Here we review some recent a …
Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiologic …
Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet.
Farrés J, Pujol A, Coma M, Ruiz JL, Naval J, Mas JM, Molins A, Fondevila J, Aloy P. Farrés J, et al. Among authors: pujol a. Nutr Metab (Lond). 2010 Dec 9;7:88. doi: 10.1186/1743-7075-7-88. Nutr Metab (Lond). 2010. PMID: 21143928 Free PMC article.
Accordingly, our aim is to reveal such a relationship between a ketogenic diet and type 2 diabetes through systems biology approaches. ...RESULTS: A strong relationship between the insulin resistance pathway and the ketosis main pathway was identified, provid …
Accordingly, our aim is to reveal such a relationship between a ketogenic diet and type 2 diabetes through systems biology app …
In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan.
Jorba G, Aguirre-Plans J, Junet V, Segú-Vergés C, Ruiz JL, Pujol A, Fernández-Fuentes N, Mas JM, Oliva B. Jorba G, et al. Among authors: pujol a. PLoS One. 2020 Feb 13;15(2):e0228926. doi: 10.1371/journal.pone.0228926. eCollection 2020. PLoS One. 2020. PMID: 32053711 Free PMC article.
Unveiling the mechanism of action of a drug is key to understand the benefits and adverse reactions of a medication in an organism. ...Exploring this collection of mechanisms is one of the clues for a future personalized medicine. The Therapeutic Performance …
Unveiling the mechanism of action of a drug is key to understand the benefits and adverse reactions of a medication in an orga …
Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems.
Herrando-Grabulosa M, Mulet R, Pujol A, Mas JM, Navarro X, Aloy P, Coma M, Casas C. Herrando-Grabulosa M, et al. Among authors: pujol a. PLoS One. 2016 Jan 25;11(1):e0147626. doi: 10.1371/journal.pone.0147626. eCollection 2016. PLoS One. 2016. PMID: 26807587 Free PMC article.
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. ...Our approach in this study was based on a holistic vision of these mechanisms and the use of …
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for wh …
The proton-pump inhibitor lansoprazole enhances amyloid beta production.
Badiola N, Alcalde V, Pujol A, Münter LM, Multhaup G, Lleó A, Coma M, Soler-López M, Aloy P. Badiola N, et al. Among authors: pujol a. PLoS One. 2013;8(3):e58837. doi: 10.1371/journal.pone.0058837. Epub 2013 Mar 8. PLoS One. 2013. PMID: 23520537 Free PMC article.
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from
Methods for diagnosing perceived age on the basis of an ensemble of phenotypic features.
Coma M, Valls R, Mas JM, Pujol A, Herranz MA, Alonso V, Naval J. Coma M, et al. Among authors: pujol a. Clin Cosmet Investig Dermatol. 2014 Apr 17;7:133-7. doi: 10.2147/CCID.S52257. eCollection 2014. Clin Cosmet Investig Dermatol. 2014. PMID: 24790464 Free PMC article.
In a society where a youthful appearance are an object of desire for consumers, and a source of commercial profit for cosmetic companies, this concept has a prominent role. ...Therefore, we have developed a method for determining the perceived a …
In a society where a youthful appearance are an object of desire for consumers, and a source of commercial profit for c …
Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features.
Vila-Cejudo M, Alonso-Alonso S, Pujol A, Santaló J, Ibáñez E. Vila-Cejudo M, et al. Among authors: pujol a. J Assist Reprod Genet. 2020 Oct 12. doi: 10.1007/s10815-020-01964-7. Online ahead of print. J Assist Reprod Genet. 2020. PMID: 33047186
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome.
García-Cazorla À, Verdura E, Juliá-Palacios N, Anderson EN, Goicoechea L, Planas-Serra L, Tsogtbaatar E, Dsouza NR, Schlüter A, Urreizti R, Tarnowski JM, Gavrilova RH; SHMT2 Working Group, Ruiz M, Rodríguez-Palmero A, Fourcade S, Cogné B, Besnard T, Vincent M, Bézieau S, Folmes CD, Zimmermann MT, Klee EW, Pandey UB, Artuch R, Cousin MA, Pujol A. García-Cazorla À, et al. Among authors: pujol a. Acta Neuropathol. 2020 Oct 5. doi: 10.1007/s00401-020-02223-w. Online ahead of print. Acta Neuropathol. 2020. PMID: 33015733 No abstract available.
CSVS, a crowdsourcing database of the Spanish population genetic variability.
Peña-Chilet M, Roldán G, Perez-Florido J, Ortuño FM, Carmona R, Aquino V, Lopez-Lopez D, Loucera C, Fernandez-Rueda JL, Gallego A, García-Garcia F, González-Neira A, Pita G, Núñez-Torres R, Santoyo-López J, Ayuso C, Minguez P, Avila-Fernandez A, Corton M, Moreno-Pelayo MÁ, Morin M, Gallego-Martinez A, Lopez-Escamez JA, Borrego S, Antiñolo G, Amigo J, Salgado-Garrido J, Pasalodos-Sanchez S, Morte B; Spanish Exome Crowdsourcing Consortium, Carracedo Á, Alonso Á, Dopazo J. Peña-Chilet M, et al. Nucleic Acids Res. 2020 Sep 29:gkaa794. doi: 10.1093/nar/gkaa794. Online ahead of print. Nucleic Acids Res. 2020. PMID: 32990755
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Bastard P, et al. Science. 2020 Oct 23;370(6515):eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. Science. 2020. PMID: 32972996
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