Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation.
Dennis PB, Pullen N, Pearson RB, Kozma SC, Thomas G.
Dennis PB, et al. Among authors: pullen n.
J Biol Chem. 1998 Jun 12;273(24):14845-52. doi: 10.1074/jbc.273.24.14845.
J Biol Chem. 1998.
PMID: 9614086
Free article.
Earlier studies showed that truncation of the p70(s6k) amino terminus severely impaired kinase activation but that this effect was reversed by deleting the carboxyl terminus, which in parallel led to deregulation of Thr229 phosphorylation in the activation loop (Dennis, P. B., …
Earlier studies showed that truncation of the p70(s6k) amino terminus severely impaired kinase activation but that this effect was reversed …