Pullen SM - Search Results

1

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Jamieson SM, Gu Y, Manesh DM, El-Hoss J, Jing D, Mackenzie KL, Guise CP, Foehrenbacher A, Pullen SM, Benito J, Smaill JB, Patterson AV, Mulaw MA, Konopleva M, Bohlander SK, Lock RB, Wilson WR. Jamieson SM, et al. Among authors: pullen sm. Biochem Pharmacol. 2014 Mar 1;88(1):36-45. doi: 10.1016/j.bcp.2013.12.019. Epub 2014 Jan 13. Biochem Pharmacol. 2014. PMID: 24434189

2

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR. Singleton RS, et al. Among authors: pullen sm. Cancer Res. 2009 May 1;69(9):3884-91. doi: 10.1158/0008-5472.CAN-08-4023. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366798

3

Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.

Abbattista MR, Jamieson SM, Gu Y, Nickel JE, Pullen SM, Patterson AV, Wilson WR, Guise CP. Abbattista MR, et al. Among authors: pullen sm. Cancer Biol Ther. 2015;16(4):610-22. doi: 10.1080/15384047.2015.1017171. Epub 2015 Apr 14. Cancer Biol Ther. 2015. PMID: 25869917 Free PMC article.

4

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: pullen sm. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

5

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

Wilson WR, Hicks KO, Pullen SM, Ferry DM, Helsby NA, Patterson AV. Wilson WR, et al. Among authors: pullen sm. Radiat Res. 2007 Jun;167(6):625-36. doi: 10.1667/RR0807.1. Radiat Res. 2007. PMID: 17523848

6

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: pullen sm. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

7

Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism.

Siim BG, Hicks KO, Pullen SM, van Zijl PL, Denny WA, Wilson WR. Siim BG, et al. Among authors: pullen sm. Biochem Pharmacol. 2000 Oct 1;60(7):969-78. doi: 10.1016/s0006-2952(00)00420-2. Biochem Pharmacol. 2000. PMID: 10974206

8

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.

Helsby NA, Ferry DM, Patterson AV, Pullen SM, Wilson WR. Helsby NA, et al. Among authors: pullen sm. Br J Cancer. 2004 Mar 8;90(5):1084-92. doi: 10.1038/sj.bjc.6601612. Br J Cancer. 2004. PMID: 14997211 Free PMC article.

9

Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.

Palmer BD, Wilson WR, Pullen SM, Denny WA. Palmer BD, et al. Among authors: pullen sm. J Med Chem. 1990 Jan;33(1):112-21. doi: 10.1021/jm00163a019. J Med Chem. 1990. PMID: 2296009

10

Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction.

Denny WA, Wilson WR, Tercel M, Van Zijl P, Pullen SM. Denny WA, et al. Among authors: pullen sm. Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):317-21. doi: 10.1016/0360-3016(94)90282-8. Int J Radiat Oncol Biol Phys. 1994. PMID: 8195026

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