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196 results

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Page 1
Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability.
Kearon C, de Wit K, Parpia S, Schulman S, Afilalo M, Hirsch A, Spencer FA, Sharma S, D'Aragon F, Deshaies JF, Le Gal G, Lazo-Langner A, Wu C, Rudd-Scott L, Bates SM, Julian JA; PEGeD Study Investigators. Kearon C, et al. N Engl J Med. 2019 Nov 28;381(22):2125-2134. doi: 10.1056/NEJMoa1909159. N Engl J Med. 2019. PMID: 31774957
BACKGROUND: Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in pat …
BACKGROUND: Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per mi …
Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer.
Wells PS, Anderson DR, Rodger M, Stiell I, Dreyer JF, Barnes D, Forgie M, Kovacs G, Ward J, Kovacs MJ. Wells PS, et al. Ann Intern Med. 2001 Jul 17;135(2):98-107. doi: 10.7326/0003-4819-135-2-200107170-00010. Ann Intern Med. 2001. PMID: 11453709
PATIENTS: 930 consecutive patients with suspected pulmonary embolism. INTERVENTIONS: Physicians first used a clinical model to determine patients' pretest probability of pulmonary embolism and then performed a D -dimer test. ...Patients for whom …
PATIENTS: 930 consecutive patients with suspected pulmonary embolism. INTERVENTIONS: Physicians first used a clinical model to …
Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report.
Stevens SM, Woller SC, Baumann Kreuziger L, Bounameaux H, Doerschug K, Geersing GJ, Huisman MV, Kearon C, King CS, Knighton AJ, Lake E, Murin S, Vintch JRE, Wells PS, Moores LK. Stevens SM, et al. Chest. 2021 Dec;160(6):2247-2259. doi: 10.1016/j.chest.2021.07.056. Epub 2021 Aug 2. Chest. 2021. PMID: 34352279
METHODS: We generate strong and weak recommendations based on high-, moderate-, and low-certainty evidence, using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology. ...
METHODS: We generate strong and weak recommendations based on high-, moderate-, and low-certainty evidence, using GRADE (Grading of R …
A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism: The SEATTLE II Study.
Piazza G, Hohlfelder B, Jaff MR, Ouriel K, Engelhardt TC, Sterling KM, Jones NJ, Gurley JC, Bhatheja R, Kennedy RJ, Goswami N, Natarajan K, Rundback J, Sadiq IR, Liu SK, Bhalla N, Raja ML, Weinstock BS, Cynamon J, Elmasri FF, Garcia MJ, Kumar M, Ayerdi J, Soukas P, Kuo W, Liu PY, Goldhaber SZ; SEATTLE II Investigators. Piazza G, et al. JACC Cardiovasc Interv. 2015 Aug 24;8(10):1382-1392. doi: 10.1016/j.jcin.2015.04.020. JACC Cardiovasc Interv. 2015. PMID: 26315743 Free article. Clinical Trial.
BACKGROUND: Systemic fibrinolysis for acute pulmonary embolism (PE) reduces cardiovascular collapse but causes hemorrhagic stroke at a rate exceeding 2%. ...(A Prospective, Single-arm, Multi-center Trial of EkoSonic Endovascular System and Activase for Treatment of …
BACKGROUND: Systemic fibrinolysis for acute pulmonary embolism (PE) reduces cardiovascular collapse but causes hemorrhagic str …
Investigation of perfusion defects by Q-SPECT/CT in patients with mild-to-moderate course of COVID-19 and low clinical probability for pulmonary embolism.
Ozturk BC, Atahan E, Gencer A, Harbiyeli DO, Karabul E, Mazıcan N, Toplutas KN, Acar HC, Sager S, Gemicioglu B, Borekci S. Ozturk BC, et al. Ann Nucl Med. 2021 Oct;35(10):1117-1125. doi: 10.1007/s12149-021-01647-y. Epub 2021 Jun 25. Ann Nucl Med. 2021. PMID: 34173212 Free PMC article.
OBJECTIVE: Pulmonary embolism is a severe source of mortality and morbidity in patients with severe and critical coronavirus disease 2019. ...METHODS: All patients who underwent Q-SPECT/CT with suspicion of embolism were examined retrospectively. Only patient …
OBJECTIVE: Pulmonary embolism is a severe source of mortality and morbidity in patients with severe and critical coronavirus d …
Diagnostic Strategies in Pulmonary Embolism.
Glazier MM, Glazier JJ. Glazier MM, et al. Int J Angiol. 2024 Feb 12;33(2):89-94. doi: 10.1055/s-0044-1779661. eCollection 2024 Jun. Int J Angiol. 2024. PMID: 38846998 Free PMC article. Review.
Key to the diagnosis of pulmonary embolism (PE) is a careful bedside evaluation. After this, there are three further diagnostic steps. ...Key studies in determining which low to moderate probability patients require chest imaging are the Age-adj …
Key to the diagnosis of pulmonary embolism (PE) is a careful bedside evaluation. After this, there are three further di …
Pulmonary Embolism and Chronic Obstructive Pulmonary Disease.
Bertoletti L, Couturaud F, Sanchez O, Jimenez D. Bertoletti L, et al. Semin Thromb Hemost. 2023 Nov;49(8):809-815. doi: 10.1055/s-0042-1756190. Epub 2022 Sep 15. Semin Thromb Hemost. 2023. PMID: 36108648 Review.
However, unlike other risk factors such as contraception, the presence of COPD can modify the initial presentation of VTE and worsen the short-term prognosis of patients who have acute pulmonary embolism (PE), particularly during a COPD exacerbation. It is not only …
However, unlike other risk factors such as contraception, the presence of COPD can modify the initial presentation of VTE and worsen the sho …
Compression stockings in addition to low-molecular-weight heparin to prevent venous thromboembolism in surgical inpatients requiring pharmacoprophylaxis: the GAPS non-inferiority RCT.
Shalhoub J, Lawton R, Hudson J, Baker C, Bradbury A, Dhillon K, Everington T, Gohel MS, Hamady Z, Hunt BJ, Stansby G, Warwick D, Norrie J, Davies AH. Shalhoub J, et al. Health Technol Assess. 2020 Dec;24(69):1-80. doi: 10.3310/hta24690. Health Technol Assess. 2020. PMID: 33275096 Free PMC article. Clinical Trial.
A combined end point of duplex ultrasound-proven new lower-limb deep-vein thrombosis (symptomatic or asymptomatic) plus imaging-confirmed symptomatic pulmonary embolism. Secondary outcomes included quality of life, compliance with graduated compression stockings and …
A combined end point of duplex ultrasound-proven new lower-limb deep-vein thrombosis (symptomatic or asymptomatic) plus imaging-confirmed sy …
An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial.
Kearon C, Ginsberg JS, Douketis J, Turpie AG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson DR, Kovacs MJ, Linkins LA, Julian JA, Bonilla LR, Gent M; Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group. Kearon C, et al. Ann Intern Med. 2006 Jun 6;144(11):812-21. doi: 10.7326/0003-4819-144-11-200606060-00007. Ann Intern Med. 2006. PMID: 16754923 Clinical Trial.
BACKGROUND: It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) who have a negative D-dimer test, but this approach has never been evaluated in a randomized, controlled trial. ...Patients were class …
BACKGROUND: It may be safe to omit additional diagnostic testing in selected patients with suspected pulmonary embolism (PE) w …
Clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in COVID-19 patients with a moderate to high pre-test probability of PE.
Das JP, Yeh R, Schöder H. Das JP, et al. Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):794-799. doi: 10.1007/s00259-020-05043-y. Epub 2020 Sep 22. Eur J Nucl Med Mol Imaging. 2021. PMID: 32959115 Free PMC article. Review.
All patients had a current diagnosis of malignancy and had a moderate or high pre-test probability for PE (mean Wells score 2.8, range 2-4). Q-SPECT/CT was positive in 4/6 (67%) of patients. ...CONCLUSION: Q-SPECT/CT has clinical utility for diagnosing PE in patient …
All patients had a current diagnosis of malignancy and had a moderate or high pre-test probability for PE (mean Wells score 2. …
196 results