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33 results
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T cell killing does not require the formation of a stable mature immunological synapse.
Purbhoo MA, Irvine DJ, Huppa JB, Davis MM. Purbhoo MA, et al. Nat Immunol. 2004 May;5(5):524-30. doi: 10.1038/ni1058. Epub 2004 Mar 28. Nat Immunol. 2004. PMID: 15048111
A peptide antagonist disrupts NK cell inhibitory synapse formation.
Borhis G, Ahmed PS, Mbiribindi B, Naiyer MM, Davis DM, Purbhoo MA, Khakoo SI. Borhis G, et al. Among authors: purbhoo ma. J Immunol. 2013 Mar 15;190(6):2924-30. doi: 10.4049/jimmunol.1201032. Epub 2013 Feb 4. J Immunol. 2013. PMID: 23382564 Free PMC article.
Linking molecular and cellular events in T-cell activation and synapse formation.
Krogsgaard M, Huppa JB, Purbhoo MA, Davis MM. Krogsgaard M, et al. Among authors: purbhoo ma. Semin Immunol. 2003 Dec;15(6):307-15. doi: 10.1016/j.smim.2003.09.002. Semin Immunol. 2003. PMID: 15001169 Review.
Direct observation of ligand recognition by T cells.
Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM. Irvine DJ, et al. Among authors: purbhoo ma. Nature. 2002 Oct 24;419(6909):845-9. doi: 10.1038/nature01076. Nature. 2002. PMID: 12397360
Dynamics of cell surface molecules during T cell recognition.
Davis MM, Krogsgaard M, Huppa JB, Sumen C, Purbhoo MA, Irvine DJ, Wu LC, Ehrlich L. Davis MM, et al. Among authors: purbhoo ma. Annu Rev Biochem. 2003;72:717-42. doi: 10.1146/annurev.biochem.72.121801.161625. Annu Rev Biochem. 2003. PMID: 14527326 Review.
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.
Purbhoo MA, Sutton DH, Brewer JE, Mullings RE, Hill ME, Mahon TM, Karbach J, J├Ąger E, Cameron BJ, Lissin N, Vyas P, Chen JL, Cerundolo V, Jakobsen BK. Purbhoo MA, et al. J Immunol. 2006 Jun 15;176(12):7308-16. doi: 10.4049/jimmunol.176.12.7308. J Immunol. 2006. PMID: 16751374
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.
Whelan JA, Dunbar PR, Price DA, Purbhoo MA, Lechner F, Ogg GS, Griffiths G, Phillips RE, Cerundolo V, Sewell AK. Whelan JA, et al. Among authors: purbhoo ma. J Immunol. 1999 Oct 15;163(8):4342-8. J Immunol. 1999. PMID: 10510374
Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
Sewell AK, Gerth UC, Price DA, Purbhoo MA, Boulter JM, Gao GF, Bell JI, Phillips RE, Jakobsen BK. Sewell AK, et al. Among authors: purbhoo ma. Nat Med. 1999 Apr;5(4):399-404. doi: 10.1038/7398. Nat Med. 1999. PMID: 10202928
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.
Xu XN, Purbhoo MA, Chen N, Mongkolsapaya J, Cox JH, Meier UC, Tafuro S, Dunbar PR, Sewell AK, Hourigan CS, Appay V, Cerundolo V, Burrows SR, McMichael AJ, Screaton GR. Xu XN, et al. Among authors: purbhoo ma. Immunity. 2001 May;14(5):591-602. doi: 10.1016/s1074-7613(01)00133-9. Immunity. 2001. PMID: 11371361
The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.
Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK. Purbhoo MA, et al. J Biol Chem. 2001 Aug 31;276(35):32786-92. doi: 10.1074/jbc.M102498200. Epub 2001 Jul 3. J Biol Chem. 2001. PMID: 11438524
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