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Page 1
A Putative Acetylation System in Vibrio cholerae Modulates Virulence in Arthropod Hosts.
Liimatta K, Flaherty E, Ro G, Nguyen DK, Prado C, Purdy AE. Liimatta K, et al. Among authors: purdy ae. Appl Environ Microbiol. 2018 Oct 17;84(21):e01113-18. doi: 10.1128/AEM.01113-18. Print 2018 Nov 1. Appl Environ Microbiol. 2018. PMID: 30143508 Free PMC article.
In summary, we demonstrate that proteins likely involved in acetylation can modulate the outcome of infection by regulating metabolite exchange between pathogens and their colonized hosts.IMPORTANCE The bacterium Vibrio cholerae causes severe disease in humans, and strains …
In summary, we demonstrate that proteins likely involved in acetylation can modulate the outcome of infection by regulating metabolite excha …
Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae.
Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR. Jørgensen R, et al. Among authors: purdy ae. J Biol Chem. 2008 Apr 18;283(16):10671-8. doi: 10.1074/jbc.M710008200. Epub 2008 Feb 14. J Biol Chem. 2008. PMID: 18276581 Free article.
We report the characterization of a novel toxin from Vibrio cholerae, which we call cholix toxin. The toxin is active against mammalian cells (IC(50) = 4.6 +/- 0.4 ng/ml) and crustaceans (Artemia nauplii LD(50) = 10 +/- 2 mug/ml). ...These results indicate that cholix toxi …
We report the characterization of a novel toxin from Vibrio cholerae, which we call cholix toxin. The toxin is active against mammali …
A glimpse into the expanded genome content of Vibrio cholerae through identification of genes present in environmental strains.
Purdy A, Rohwer F, Edwards R, Azam F, Bartlett DH. Purdy A, et al. J Bacteriol. 2005 May;187(9):2992-3001. doi: 10.1128/JB.187.9.2992-3001.2005. J Bacteriol. 2005. PMID: 15838025 Free PMC article.
Vibrio cholerae has multiple survival strategies which are reflected both in its broad distribution in many aquatic environments and its high genotypic diversity. ...Gene transfer among these strains could be facilitated by a 4.9-kbp plasmid discovered in one isolate, whic …
Vibrio cholerae has multiple survival strategies which are reflected both in its broad distribution in many aquatic environments and …
Diversity and distribution of cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae.
Purdy AE, Balch D, Lizárraga-Partida ML, Islam MS, Martinez-Urtaza J, Huq A, Colwell RR, Bartlett DH. Purdy AE, et al. Environ Microbiol Rep. 2010 Feb;2(1):198-207. doi: 10.1111/j.1758-2229.2010.00139.x. Environ Microbiol Rep. 2010. PMID: 23766017
Non-toxigenic non-O1, non-O139 Vibrio cholerae strains isolated from both environmental and clinical settings carry a suite of virulence factors aside from cholera toxin. ...
Non-toxigenic non-O1, non-O139 Vibrio cholerae strains isolated from both environmental and clinical settings carry a suite of virule …
Fly Models of Vibrio cholerae Infection and Colonization.
Purdy AE. Purdy AE. Methods Mol Biol. 2018;1839:77-96. doi: 10.1007/978-1-4939-8685-9_8. Methods Mol Biol. 2018. PMID: 30047056
Studies of Vibrio cholerae pathogenesis in the context of novel eukaryotic model systems have expanded our understanding of genes that underlie V. cholerae interactions with humans, as well as host organisms in the environment. ...
Studies of Vibrio cholerae pathogenesis in the context of novel eukaryotic model systems have expanded our understanding of genes tha …
Modulation of CrbS-Dependent Activation of the Acetate Switch in Vibrio cholerae.
Muzhingi I, Prado C, Sylla M, Diehl FF, Nguyen DK, Servos MM, Flores Ramos S, Purdy AE. Muzhingi I, et al. Among authors: purdy ae. J Bacteriol. 2018 Nov 6;200(23):e00380-18. doi: 10.1128/JB.00380-18. Print 2018 Dec 1. J Bacteriol. 2018. PMID: 30224439 Free PMC article.
Vibrio cholerae controls the pathogenicity of interactions with arthropod hosts via the activity of the CrbS/R two-component system. ...
Vibrio cholerae controls the pathogenicity of interactions with arthropod hosts via the activity of the CrbS/R two-component system. …
Vibrio cholerae laboratory infection of the adult house fly Musca domestica.
El-Bassiony GM, Luizzi V, Nguyen D, Stoffolano JG Jr, Purdy AE. El-Bassiony GM, et al. Among authors: purdy ae. Med Vet Entomol. 2016 Dec;30(4):392-402. doi: 10.1111/mve.12183. Epub 2016 Jul 22. Med Vet Entomol. 2016. PMID: 27444689
The present study was designed to test the hypothesis that house flies may be capable of specifically harbouring ingested Vibrio cholerae in their digestive tracts. Flies were continuously fed green fluorescent protein (GFP)-labelled, non-O1/non-O139 environmental strains …
The present study was designed to test the hypothesis that house flies may be capable of specifically harbouring ingested Vibrio chol …
Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host.
Kamareddine L, Wong ACN, Vanhove AS, Hang S, Purdy AE, Kierek-Pearson K, Asara JM, Ali A, Morris JG Jr, Watnick PI. Kamareddine L, et al. Among authors: purdy ae. Nat Microbiol. 2018 Feb;3(2):243-252. doi: 10.1038/s41564-017-0065-7. Epub 2017 Nov 27. Nat Microbiol. 2018. PMID: 29180725 Free PMC article.
Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aquatic environment. ...
Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aq …
The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.
Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. Hang S, et al. Among authors: purdy ae. Cell Host Microbe. 2014 Nov 12;16(5):592-604. doi: 10.1016/j.chom.2014.10.006. Epub 2014 Nov 12. Cell Host Microbe. 2014. PMID: 25525791 Free PMC article.
Vibrio cholerae is lethal to the model host Drosophila melanogaster through mechanisms not solely attributable to cholera toxin. ...
Vibrio cholerae is lethal to the model host Drosophila melanogaster through mechanisms not solely attributable to cholera toxin. ...
Regulation of acetyl-CoA synthetase transcription by the CrbS/R two-component system is conserved in genetically diverse environmental pathogens.
Jacob K, Rasmussen A, Tyler P, Servos MM, Sylla M, Prado C, Daniele E, Sharp JS, Purdy AE. Jacob K, et al. Among authors: purdy ae. PLoS One. 2017 May 18;12(5):e0177825. doi: 10.1371/journal.pone.0177825. eCollection 2017. PLoS One. 2017. PMID: 28542616 Free PMC article.
During infection, bacteria can utilize this system to hijack host acetate metabolism and alter the course of colonization and pathogenesis. In toxigenic strains of Vibrio cholerae, CrbS/R-dependent expression of acsA is required for virulence in an arthropod model. ...
During infection, bacteria can utilize this system to hijack host acetate metabolism and alter the course of colonization and pathogenesis. …
13 results